DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20170818

Prescribing pattern in patients of asthma visiting outpatient departments of a tertiary care hospital: a cross-sectional, observational study

Nitant Trivedi, Hemangini R. Acharya, Manish J. Barvaliya, C. B. Tripathi

Abstract


Background: Objective of the study was to evaluate the prescribing pattern in patients of asthma visiting outpatient departments.

Methods: Collected prescriptions were analyzed for demographic variables, proportions of various comorbid conditions, average number of drugs per prescription, average number of anti-asthmatic drugs per prescription, proportion of prescription with antibiotics, fixed dose combinations, and generic/brand names, proportion of formulations utilized, proportion of concomitant medications and possible drug interactions, average cost per prescription, average cost of antiasthmatic drugs per prescription, proportion of irrational prescription and adverse drug reactions.

Results: Total 139 prescriptions were evaluated. Deriphyllin was the most commonly prescribed anti-asthmatic drug followed by beta agonist- steroid combination. Majority drugs were prescribed by inhalational route. Deriphyllin, and dexamethasone were prescribed by oral route and salbutamol was by both oral and inhalational route of administration. Antibiotics were prescribed to 24 patients. Possible drug interaction with deriphyllin was found in 15 prescriptions. Average cost per prescription was Rs. 193.4 (95%CI: 171.6-215.3).

Conclusions: Prescribing pattern of asthma in our hospital shows more use of anti-asthmatic drugs. Standard treatment guideline should be followed. Role of methylxanthine in long term management of asthma should be justified.


Keywords


Bronchial asthma, Fixed dose combinations, Prescription audit, Poly-pharmacy

Full Text:

PDF

References


Global Strategy for Asthma Management and Prevention; 2010. Available from: http://www.ginasthma.org/pdf/GINA_Report_2010.pdf

Pandey A, Tripathi P, Pandey RD. Prescription pattern in asthma therapy at Gorakhpur hospitals, Lung India. 2010;27(1):8-10.

Martinez FD. Genes, environments, development and asthma: a reappraisal. Eur Respir J. 2007;29(1):179-84.

Lemanske RF, Busse WW. Asthma: clinical expression and molecular mechanisms. J. Allergy Clin. Immunol. 2010;125(2):S95-102.

Yawn BP. Factors accounting for asthma variability: achieving optimal symptom control for individual patients. Prim Care Respir J. 2008;17(3):138-47.

NAEPP Expert Panel Report: guidelines for the diagnosis and management of asthmaupdates on selected topics 2007. Available from: http://www.nhlbi.nih.gov/guidelines/asthma

Tan H, Sarawate C, Singer J, Elward K, Cohen RI, Smart BA. Impact of Asthma Controller Medications on Clinical, Economic, and Patient-Reported Outcomes. Mayo Clin Proc. 2009;84(8):675-84.

Shimpi RD, Salunkhe PS, Bavaskar SR, Laddha GP, Kalam A, Patel KH. Drug utilization evaluation and prescription monitoring in asthmatic patients. Int J Pharm Biolog Sci. 2012;2:117-22.

Tripathi KD, editor. Essentials of Medical Pharmacology. 6th ed. New Delhi: Jaypee Brothers Medical Publishers (P) LTD; 2009:221.

Srivastava R, Sharma S, Keshri L, Wal P. Assessment of prescription pattern in asthma therapy at Shamli hospitals. Rev Recent Clin Trials. 2012;7(2):158-64.

Kumar SV, Kala MS, Mohamed TS, Gauthaman K. Drug utilization and prescription monitoring of asthma patients. J Young Pharmacists. 2009;1:180-3.