Metronidazole associated seizures: a case report and review of the pharmacovigilance literature


  • Olayinka A. Ogundipe Consultant Physician, Department of Medicine of the Elderly, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, UK


Metronidazole, Adverse drug reaction, Seizures, Causality, Adverse drug reaction reporting systems, Pharmacovigilance


Seizures are a rare side-effect associated with the use of metronidazole. This report describes the case of an 83-year old patient with previous cerebral injury in whom new onset seizures were triggered soon after the commencement of treatment with metronidazole at conventional adult doses for Clostridium difficile-associated diarrhoea.

A brief review of the medical pharmacovigilance literature in relation to metronidazole and seizures is presented. Two causality assessment systems are applied to the index case report, to illustrate their potential use in supporting increased objectivity when reporting suspected ADRs in clinical practice.


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How to Cite

Ogundipe, O. A. (2017). Metronidazole associated seizures: a case report and review of the pharmacovigilance literature. International Journal of Basic & Clinical Pharmacology, 3(1), 235–238. Retrieved from