Alcoholism with central pontine demyelination: a case report
Keywords:
Central pontine myelinolysis, Demyelinating disease, Chronic alcoholismAbstract
Central pontine myelinolysis is a non-inflammatory demyelinating disease characterized by loss of myelin with relative neuron sparing, associated with rapid correction of hyponatremia and sometimes hypernatremia or chronic alcoholism. We are reporting a case of 52 year old male patient who was chronic alcoholic from past 20 years, presented to us with complaints of altered sensorium and dysarthria of 5 days duration .He was investigated and diagnosed as case of central pontine myelinosis associated with chronic alcoholism.
References
Gocht A, Colmant HJ. "Central pontine and extrapontine myelinolysis: a report of 58 cases". Clin. Neuropathol. 1987;6(6):262–70.
Adams RA, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholics and malnourished patients. Arch Neurol Psychiatry. 1959;81:154-72.
Koci TM, Chiang F, Chow P, et al. Thalamic extrapontine lesions in central pontine myelinolysis. Am J Neuroradiol. 1990;11:1229-33.
Miller GM, Baker HL Jun, Okozaki H, Whisnant JP. Central pontine myelinolysis and its imitators: MR findings. Radiology. 1988;168:795-802.
Clark WR. Diffuse demyelinating lesions of the brain after the rapid development of hypernatremia. West J Med. 1992;157:571-3.
Howard LS, Krishna Rao CVG, Zimmerman RA. Cranial MRI and CT. 3rd ed. New York, NY: Mc Graw-Hill; 1999: 606-608.
Robin A. Hurley, Christopher M. Filley, Katherine H. Taber, Central Pontine Myelinolysis: A Metabolic Disorder of Myelin. J Neuropsychiatry Clin Neurosci. 2011Fab11;23(4):369-74.
Koragi Y, Takahashi M, Shinzaho J, et al. MR findings in two presumed cases of mild central pontine myelinolysis. Am J Neuoradiol. 1995;14:651-4.
Mochizuki H, Masaki T, Miyakawa T, et al. Benign type of central pontine myelinolysis in alcoholism: clinical, neuroradiological, and electrophysiological findings. J Neurol. 2003;250:1077–83.
