Alcoholism with central pontine demyelination: a case report

Authors

  • Rohit Arora Department of Medicine, Subharti Medical College, Meerut – 250005, Uttar Pradesh, India
  • Rahul Singhal Department of Medicine, Subharti Medical College, Meerut – 250005, Uttar Pradesh, India
  • Sunil Kumar Virmani Department of Medicine, Subharti Medical College, Meerut – 250005, Uttar Pradesh, India
  • Abhishek Gupta Department of Medicine, Subharti Medical College, Meerut – 250005, Uttar Pradesh, India

Keywords:

Central pontine myelinolysis, Demyelinating disease, Chronic alcoholism

Abstract

Central pontine myelinolysis is a non-inflammatory demyelinating disease characterized by loss of myelin with relative neuron sparing, associated with rapid correction of hyponatremia and sometimes hypernatremia or chronic alcoholism. We are reporting a case of 52 year old male patient who was chronic alcoholic from past 20 years, presented to us with complaints of altered sensorium and dysarthria of 5 days duration .He was investigated and diagnosed as case of central pontine myelinosis associated with chronic alcoholism.

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References

Gocht A, Colmant HJ. "Central pontine and extrapontine myelinolysis: a report of 58 cases". Clin. Neuropathol. 1987;6(6):262–70.

Adams RA, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholics and malnourished patients. Arch Neurol Psychiatry. 1959;81:154-72.

Koci TM, Chiang F, Chow P, et al. Thalamic extrapontine lesions in central pontine myelinolysis. Am J Neuroradiol. 1990;11:1229-33.

Miller GM, Baker HL Jun, Okozaki H, Whisnant JP. Central pontine myelinolysis and its imitators: MR findings. Radiology. 1988;168:795-802.

Clark WR. Diffuse demyelinating lesions of the brain after the rapid development of hypernatremia. West J Med. 1992;157:571-3.

Howard LS, Krishna Rao CVG, Zimmerman RA. Cranial MRI and CT. 3rd ed. New York, NY: Mc Graw-Hill; 1999: 606-608.

Robin A. Hurley, Christopher M. Filley, Katherine H. Taber, Central Pontine Myelinolysis: A Metabolic Disorder of Myelin. J Neuropsychiatry Clin Neurosci. 2011Fab11;23(4):369-74.

Koragi Y, Takahashi M, Shinzaho J, et al. MR findings in two presumed cases of mild central pontine myelinolysis. Am J Neuoradiol. 1995;14:651-4.

Mochizuki H, Masaki T, Miyakawa T, et al. Benign type of central pontine myelinolysis in alcoholism: clinical, neuroradiological, and electrophysiological findings. J Neurol. 2003;250:1077–83.

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Published

2017-01-23

How to Cite

Arora, R., Singhal, R., Virmani, S. K., & Gupta, A. (2017). Alcoholism with central pontine demyelination: a case report. International Journal of Basic & Clinical Pharmacology, 3(1), 230–232. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/985