Clindamycin as trigger of uroporphyrinuria


  • Mario Stefanini Clinch Valley Medical Center, Richlands, Virginia USA


Clindamycin, Uroporphyrinuria, Rash


Administration of clindamycin for the management of a staphylococcal abscess of the abdominal wall was followed by development of a non-pruriginous, macular, blistery rash involving the areas of the body exposed to sunlight.  This was accompanied by significant elevation of urinary uroporphyrin possibly related to the ability of clindamycin to inhibit the enzyme CYP3A4 of the P450 system.


Wynalda MA, Hutzler JM, Koets M, Podoll T, Wienkers LC. In Vitro Metabolism of Clindamycin in Human Liver and Intestinal Microsomes. Amer Soc for Pharmacology and Experimental Therapeutics. 2003;31:878-87.

DeHaan RM, Metzler CM, Schellenberg D, VandenBosch WD, Masson EL. Pharmacokinetic Studies of Clindamycin Hydrochloride in Humans. Int J Clin Pharm. 1972;6:105-19.




How to Cite

Stefanini, M. (2017). Clindamycin as trigger of uroporphyrinuria. International Journal of Basic & Clinical Pharmacology, 3(1), 225–226. Retrieved from