Clindamycin as trigger of uroporphyrinuria

Mario Stefanini

Abstract


Administration of clindamycin for the management of a staphylococcal abscess of the abdominal wall was followed by development of a non-pruriginous, macular, blistery rash involving the areas of the body exposed to sunlight.  This was accompanied by significant elevation of urinary uroporphyrin possibly related to the ability of clindamycin to inhibit the enzyme CYP3A4 of the P450 system.


Keywords


Clindamycin, Uroporphyrinuria, Rash

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References


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DeHaan RM, Metzler CM, Schellenberg D, VandenBosch WD, Masson EL. Pharmacokinetic Studies of Clindamycin Hydrochloride in Humans. Int J Clin Pharm. 1972;6:105-19.