A comparative study for antinociceptive potential of vitamin D3 with diclofenac in animal models


  • Abhinav David Department of Pharmacology, LLRM Medical College, Meerut, Uttar Pradesh, India
  • Raj Kumar Goel Department of Pharmacology, LLRM Medical College, Meerut, Uttar Pradesh, India
  • Prashant Patel Tata Consultancy Services, Mumbai, Maharashtra, India
  • Priyadarshani Paul Department of Radiodiagnosis, RPGMC, Tanda, Kangra, Himachal Pradesh, India




Antinociception, Calcitriol, Diclofenac, Tail pinch, Writhing


Background: Calcitriol is one of the active forms of vitamin D. It not only acts on calcium metabolism but might have a role in treating various disorders also through vitamin D receptors that are present in many tissues besides intestine and bone. This study was conducted to compare antinociceptive activity of Calcitriol with Diclofenac and Morphine in animal models.

Methods: In this study, healthy Swiss albino mice were taken after permission from IAEC. Mice were divided into six groups as one control- treated with normal saline, two standards - treated with diclofenac and treated with morphine while three tests - treated with Calcitriol in dose of 15µg /kg/mice, 30µg/kg/mice and 60µg/kg/mice respectively. Comparison of antinociception was done using Tail pinch and writhing method.

Results: Tail pinch and Writhing methods were used for comparison of antinociceptive activity. In tail pinch model, Calcitriol showed some analgesia at 30 and 60μg/Kg doses, which was more than control but not comparable with the standard Morphine. In writhing method, test doses of Calcitriol (15 and 30μg/Kg) failed to show analgesic efficacy in inflammatory pain but test dose of 60μg/Kg showed some analgesic activity which was not comparable with standard Diclofenac.

Conclusions: Antinociception was exhibited at higher doses of Calcitriol by tail pinch method while in writhing method analgesic activity was shown with only 60 μg/Kg dose of Calcitriol. The results obtained from this study needs to be further evaluated by planning extensive animal experimentation.


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How to Cite

David, A., Goel, R. K., Patel, P., & Paul, P. (2017). A comparative study for antinociceptive potential of vitamin D3 with diclofenac in animal models. International Journal of Basic & Clinical Pharmacology, 6(3), 608–612. https://doi.org/10.18203/2319-2003.ijbcp20170822



Original Research Articles