Pattern of adverse drug reactions with chemotherapeutic drugs in a tertiary care hospital of North India: a retrospective study

Amita Jindal; B. K. Brar; Raj Kumar; Sumir Kumar; Kiranjit Sidhu; Amandeep Kaur; Richa; Rakesh Tilak Raj

doi:10.18203/2319-2003.ijbcp20230394

Authors

Amita Jindal Department of Pharmacology, Government GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab, India
B. K. Brar Department of Skin and VD, Government GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab, India
Raj Kumar Department of Pharmacology, Government GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab, India
Sumir Kumar Department of Skin and VD, Government GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab, India
Kiranjit Sidhu Department of Pulmonary Medicine, Government GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab, India
Amandeep Kaur Department of Pharmacology, Government GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab, India
Richa Department of Pharmacology, Government GGS Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot, Punjab, India
Rakesh Tilak Raj Department of Skin and VD, Government Medical College, Amritsar, Punjab, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20230394

Keywords:

Pharmacovigilance, Cutaneous manifestation of adverse drug reaction, Chemotherapeutic drugs, Antimicrobial drugs, Anticancer drugs, Retrospective study

Abstract

Background: Adverse drug reactions are important causes of mortality and morbidity in the patients. Early detection, evaluation and monitoring of ADRs is essential to improve public health.

Methods: This was an observational, non-interventional and retrospective study conducted at the ADR monitoring centre of a tertiary care hospital of North India. Suspected ADR forms reported over a period of 4 years involving at least one chemotherapeutic drug with at least one dose were analyzed.

Results: A total of 261 chemotherapeutic drugs associated ADRs were analyzed. Out of these, maximum numbers of ADRs were reported by males (54%). Maximum reporting was done by Skin and VD department (37.93%). Causality assessment was probable in maximum number of cases (54%). Most common ADRs were skin rashes (21.46%), followed by jaundice, urticaria and fixed drug eruptions. Maximum ADRs were suspected to be caused by Anti tubercular drugs (31.42%) followed by anticancer drugs (14.56%).

Conclusions: ADRs due to antibiotics and anticancer drugs is a significant health problem.

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