Published: 2021-04-26

Intravenous ondansetron induced hypersensitivity reaction: a case report

S. Nitya, M. Shanthi, R. Meenakshi, S. Kiruthika


Ondansetron a selective 5-HT3 receptor antagonist has been widely used as a prophylactic antiemetic for chemotherapy induced and anaesthesia related nausea and vomiting. Anaphylaxis and anaphylactoid reaction rarely occur in less than 1% of the patients and may lead to potentially life-threatening events. This study is one such rare case report of hypersensitivity reaction to intravenous ondansetron in a perioperative setting. Familiarity about anaphylactoid reactions to intravenous ondansetron among the health practitioners would help them to bring about a rational approach to decrease its incidence.


Ondansetron, Adverse drug reaction, Intravenous, Hypersensitivity

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Ye JH, Ponnudurai R, Schaefer R. Ondansetron: a selective 5-HT(3) receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001;7(2):199-213.

Smith RN. Safety of ondansetron. Eur J Cancer Clin Oncol. 1989;25(1):S47-50.

Lagopoulos V, Gigi E. Anaphylactic and anaphylactoid reactions during the perioperative period. Hippokratia. 2011;15:138.

Ross AK, Ferrero-Conover D. Anaphylactoid reaction due to the administration of ondansetron in a pediatric neurosurgical patient. Anesth Analg. 1998;87:779-80

Chen M, Tanner A, Gallo-Torres H. Anaphylactoid-anaphylactic reactions associated with ondansetron. Ann Intern Med. 1993;119(8):862.

Kossey JL, Kwok KK. Anaphylactoid reactions associated with ondansetron. Ann Pharmacother. 1994;28(9):1029-30.

Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100:S1-148.