Study of anti-inflammatory activity of Ficus racemosa linn stem bark extract in albino rats


  • Priya Mohan B. N. Department of Pharmacology, Al Azhar Medical College and Super Speciality Hospital, Thodupuzha, Kerala, India
  • Suma Jayaram Department of Pharmacology, St. John’s Medical College and Super Speciality Hospital, Bangalore, Karnataka, India
  • Sanitha Kuriachan Department of Pharmacology, Al Azhar Medical College and Super Speciality Hospital, Thodupuzha, Kerala, India



Anti-Inflammatory agents, Carrageenan, Diclofenac, Edema, Ficus, Granuloma, Peritonitis


Background: Inflammation is part of the complex biological response of vascular tissues to harmful stimuli. Though there are standard anti-inflammatory drugs like aspirin, diclofenac, etc., these are not free of side effects. This has led to an increase in demand for natural products with anti-inflammatory activity having less side effects. Hence the study was conducted to evaluate the anti-inflammatory activity of ethanolic extract of Ficus racemose (EEFR) in albino rats.

Methods: Healthy albino rats of either sex were divided into 4 groups of 6 animals each. Group1-control, group 2-diclofenac sodium 2 mg/kg and group 3 and 4 EEFR (200 and 400 mg/kg respectively), anti-inflammatory activity was evaluated by Carrageenan induced paw oedema: formalin induced-peritonitis and cotton pellet induced granuloma model for in vivo activity and protein denaturation test for in vitro activity.

Results: EEFR exhibited significant in vitro (p<0.001) anti-inflammatory effect at the dose of 200 and 400 mg/kg. EEFR produced 61.37% inhibition at the dose of 400 mg/kg and diclofenac (standard drug) produced 62.95% of inhibition after 3 hours of drug treatment in carrageenan induced paw oedema. The exudate volume was decreased in formalin induced peritonitis by EEFR and diclofenac significantly (p<0.001). In cotton pellet induced granuloma EEFR (400 mg/kg) and diclofenac showed decreased formation of granuloma by 28.36% and 28.00% (p<0.001) respectively.

Conclusions: EEFR has significant anti-inflammatory activity in both acute and chronic model in a dose dependant manner in comparison with standard drug.

Author Biography

Priya Mohan B. N., Department of Pharmacology, Al Azhar Medical College and Super Speciality Hospital, Thodupuzha, Kerala, India



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How to Cite

B. N., P. M., Jayaram, S., & Kuriachan, S. (2021). Study of anti-inflammatory activity of Ficus racemosa linn stem bark extract in albino rats. International Journal of Basic & Clinical Pharmacology, 10(3), 231–237.



Original Research Articles