DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20203633

The spontaneous motor activity of aqueous extract of Withania coagulans fruits in Swiss albino mice by actophotometer

Devesh D. Gosavi, Amit S. Kamdi, Suvarna M. Kalambe, Pankaj N. Bohra

Abstract


Background: People spend about one third of their time in sleep every day. The various sedative and hypnotic medications used today have numerous side effects. In the late seventies a very little work was done on the Withania coagulans - a vulnerable species that is found scattered in the world. Therefore, it was essential to discover the CNS depressant activities of aqueous extract of Withania coagulans fruits in swiss albino mice by using actophotometer.

Methods: The spontaneous locomotor activity was evaluated by using the actophotometer. The CNS depressant drugs decrease the locomotor activity in mice as they impair the motor coordination so that mice stay at one place for the longer time. Therefore, there is less disruption of the beams of light. This spontaneous locomotor activity time is statistically correlated among the control, standard and the test drugs.

Results: There was statistically highly significant (p value <0.001) association observed between aqueous extract of Withania coagulans fruits with spontaneous locomotor activity in swiss albino mice on the actophotometer.

Conclusions: The aqueous extract of Withania coagulans fruits demonstrated the CNS depressant activity in swiss albino mice by actophotometer.


Keywords


CNS depressant, Actophotometer, Swiss albino mice, Withania coagulans

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