The safety and efficacy of oral Arborium plus, a herbal liquid formulation in the treatment of diabetic foot syndrome: an open label study

Pallavi Chalivendra; Nurul Hameed Shaik; Hari Prasad Balapalli; Murali Krishna Parasaram; Bhavya Bommadi; Sai Anjani Ravanam; Subha Attili

doi:10.18203/2319-2003.ijbcp20201101

Authors

Pallavi Chalivendra Department of Pharmacology, Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India
Nurul Hameed Shaik Department of General Surgery, Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India
Hari Prasad Balapalli Department of General Surgery, Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India
Murali Krishna Parasaram Department of Panchakarma, SV Ayurvedic College and Hospital, Tirupati, Andhra Pradesh, India
Bhavya Bommadi Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India
Sai Anjani Ravanam Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India
Subha Attili Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20201101

Keywords:

Oral Arborium plus, Diabetic foot ulcer, Type-2 diabetes, Herbal formulation

Abstract

Background: Diabetic foot ulcers are the most universal cause of non-traumatic amputations of the foot in developing countries. One of the treatment modalities is to improve the peripheral blood supply to the area of ulcer. To this purpose the study was done to evaluate the safety and efficacy of oral Arborium plus (herbal liquid formulation) in the wound closure of diabetic foot patients.

Methods: 50 patients were randomly assigned to either of the groups (each group 25 patients) to receive either the test drug (Arborium plus) at tertiary care teaching hospital, it was an open label prospective and interventional parallel group study to evaluate the efficacy and safety of Arborium plus in diabetic foot syndrome. The study participants were randomized into control and intervention groups. Base line measurements of vascular flow was ankle- brachial pressure index (ABPI) and wound size measurement.

Results: The baseline characteristics of the patients age in years test and control group 68±12.3 and 67±13.4 respectively. Male/female in both groups was 21/4 and 22/3 respectively. Duration of diabetes in years 8.65±8.3 and 8.5±7.6 respectively. BMI was 25.11±4.15 and 24.75±0.85, duration of smoking (years) 17.3±9.5 and 19.5±10.5 respectively in both groups. Among the test group who received the proprietary formulation of Arborium plus, there was a significant reduction in the wound size.

Conclusions: Wound healing and ABPI improvements were observed with usage of Arborium plus suggest an improvement in peripheral vascular flow in diabetic foot subjects.

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Author Biography

Pallavi Chalivendra, Department of Pharmacology, Sri Padmavathi Medical College for Women, Tirupati, Andhra Pradesh, India

Resident, Department of General Surgery, Sri Padmavathi Medical College for Women Hospital, Tirupati

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