A retrospective study of antimicrobial usage in wound healing

Authors

  • Bhavishya Keerthi Anna Valder Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Nalini G. K. Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Shankara K. Department of Surgery, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Deepak P. Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Sahana G. N. Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Jayashree V. N. Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Neelamma . Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20201193

Keywords:

Drug utilization study, Prescription auditing, Wound healing

Abstract

Background: Chronic wounds are responsible for increase in burden to healthcare systems. The evidence concerning effectiveness of antibiotic therapy or optimal regimens is insufficient. Patients with chronic wounds receive significantly more systemic and topical antibiotics. Current guidelines for antibiotic prescribing for such wounds are often based on expert opinion rather than scientific fact. As there is increasing prevalence of antibiotic resistance, the relationships between antibiotic resistance and rationales for antibiotic therapy have to be determined. Current practice of antibiotic usage for chronic wounds and postoperative wounds in a tertiary care setting should be studied.

Methods: Retrospective study was conducted from February 2017 to February 2018 using medical records of patients with wound admitted in surgical departments in HIMS, Hassan, Karnataka. The inpatient records were analysed, which includes duration of stay in the hospital, number of drugs/products per person, percentage of antibiotics prescribed, percentage of antibiotic injection prescribed, and other modalities used to treat wounds.

Results: In present study, amongst 100 antimicrobial prescriptions, 26 females and 74 males. The most commonly prescribed parenteral antibiotic was ceftriaxone (58%), followed by metronidazole (56%). The average number of antibiotics per prescription was 2.8. The mean duration parenteral antibiotics given was 4.26 days during their hospital stay oral antibiotics were 5.18 days after the discharge from the hospital.

Conclusions: The information generated shall be used to decide the policies to govern the prescription of antibiotics in the management of chronic wounds and post-operative wounds.

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References

Hersh AL, Gonzales R. Decreasing out-of-pocket costs of antibiotics: the good, the bad, and the unknown: comment on “ambulatory antibiotic use and prescription drug coverage in older adults”. Arch Intern Med. 2010;170(15):1314-6.

Arnold SR, Straus SE. Interventions to improve antibiotic prescribing practices in ambulatory care. Cochrane database Syst Rev. 2005(4):623-90.

Sumpradit N, Chongtrakul P, Anuwong K, Pumtong S, Kongsomboon K, Butdeemee P, et al. Antibiotics Smart Use: a workable model for promoting the rational use of medicines in Thailand. BullWorld Health Organization. 2012;90:905-13.

Baktygul K, Marat B, Ashirali Z, Harun-Or-Rashid MD, Sakamoto J. An assessment of antibiotics prescribed at the secondary health-care level in the Kyrgyz Republic. Nagoya J Med Sci. 2011;73(3-4):157.

Meyer E, Gastmeier P, Deja M, Schwab F. Antibiotic consumption and resistance: data from Europe and Germany. Int J Med Microbiol. 2013;303(6-7):388-95.

Shapiro DJ, Hicks LA, Pavia AT, Hersh AL. Antibiotic prescribing for adults in ambulatory care in the USA, 2007-09. J Antimicrob Chemother. 2014;69(1):234-40.

Al-Niemat SI, Bloukh DT, Al-Harasis MD, Al-Fanek AF, Salah RK. Drug use evaluation of antibiotics prescribed in a Jordanian hospital outpatient and emergency clinics using WHO prescribing indicators. Saudi Med J. 2008;29(5):743-8.

Moghadamnia AA, Mirbolooki MR, Aghili MB. General practitioner prescribing patterns in Babol city, Islamic Republic of Iran. Eastern Mediterr Health J. 2002;8(‎‎‎4-5)‎‎‎:550-5.

Sharif SI, Al-Shaqra M, Hajjar H, Shamout A, Wess L. Patterns of drug prescribing in a hospital in Dubai, United Arab Emirates. Libyan J Med. 2008;3(1):10-2.

World Health Organization. How to investigate drug use in health facilities: selected drug use indicators-EDM Research Series No. 007; 1993.

Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Med Chem. 2014;6:S14459.

Bantar C, Vesco E, Heft C, Salamone F, Krayeski M, Gomez H, et al. Replacement of broad-spectrum cephalosporins by piperacillin-tazobactam: impact on sustained high rates of bacterial resistance. Antimicrob Agents Chemother. 2004;48(2):392-5.

Okeke IN, Aboderin OA, Byarugaba DK, Ojo KK, Opintan JA. Growing problem of multidrug-resistant enteric pathogens in Africa. Emerg Infect Dis. 2007;13(11):1640.

Petti CA, Polage CR, Quinn TC, Ronald AR, Sande MA. Laboratory medicine in Africa: a barrier to effective health care. Clin Infect Dis. 2006;42(3):377-82.

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Published

2020-03-24

How to Cite

Valder, B. K. A., G. K., N., K., S., P., D., G. N., S., V. N., J., & ., N. (2020). A retrospective study of antimicrobial usage in wound healing. International Journal of Basic & Clinical Pharmacology, 9(4), 647–651. https://doi.org/10.18203/2319-2003.ijbcp20201193

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Original Research Articles