Pharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicam

Authors

  • Saber El Hanbally Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt
  • Hanem El Gendy Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt
  • Hanem El Gendy Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt
  • Mohamed El Hewaity Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Egypt
  • Mohamed El Hewaity Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Egypt

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20201095

Keywords:

Kinetic, Cefquinome, Meloxicam, Intramuscular, Goats

Abstract

Background: Nonsteroidal anti-inflammatory drugs and antibiotics are commonly prescribed together. We aimed to study the kinetic profile of cefquinome (2 mg/kg b.wt.) following intramuscular administration of it alone and co-administered with meloxicam (0.2 mg/kg b.wt.) in goats.

Methods: Five Egyptian Baladi goats, each goat was injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome into the deep gluteal muscle of hindquarter alone and then after fifteen days washout period, these animals also injected intramuscularly at the dose rate of 2 mg/kg b.wt. Cefquinome preceded with meloxicam at the dose rate of 0.2 mg/kg b.wt. The serum concentrations of cefquinome were detected by high performance liquid chromatography, two compartment model.

Results: Following a single dose intramuscular administration of cefquinome alone, peak plasma concentration (1.71±0.0189 μg/ml) was obtained at 1.59±0.0038 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (area under concentration (AUC(0-inf)) of cefquinome were 0.4±0.0028 h, 0.068±0.78 l/h/kg, 9.21±0.178h and 29.36±0.78 µg.h.ml-1, respectively. Following a single dose intramuscular co-administration of cefquinome and meloxicam, peak plasma concentration (1.60±0.0124 μg/ml) was obtained at 1.49±0.0092 h. The absorption half-life (t1/2ab), total body clearance (Cltot), elimination half-life (t1/2el) and area under curve (AUC(0-inf)) of cefquinome were 0.396±0.006 h, 0.094±0.25 l/h/kg, 6.5±0.221 h and 21.38±0.696 µg/h/ml, respectively. Non significant alters were reported in the parameters following co-administration of Cefquinome with meloxicam.

Conclusions: From our results, may be concluded that intramuscular administration of meloxicam may be successfully co-administrated with cefquinome for combating bacterial infections with an inflammatory condition in goats without any antagonistic effect.

Author Biography

Saber El Hanbally, Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt

pharmacology

References

Rana MP, Sadariya KA, Thaker AM. Effect of tolfenamic acid co-administration on pharmacokinetics of cefquinome following intramuscular administration in sheep. Vet. Arhiv, 2015;85(3):283-92.

Tiwari S, Bhavsar SK, Patel RL, Patel JH, Varia RD, Modi FD, et al. Effect of meloxicam co-administration and febrile state on pharmacokinetic of cefquinome in goats. J Veterinary Pharmacol Toxicol. 2016;14(2):8-11.

Hwang YH, Song IB, Lee HK, Kim TW, Kim MS, Lim JH, et al. Pharmacokinetics and bioavailability of Cefquinome in rabbits following intravenous and intramuscular administration. J Vet Pharmacol Therap. 2011;34:618-20.

Thomas E, Thomas V & Wilhelm C. Antibacterial activity of Cefquinome against equine bacterial pathogens. Vet Microbiol. 2006;115:140-7.

Gupta SK, Bansal P, Bhardwaj R K, Jaiswal J & Velpandian T. Comparison of analgesic and anti-inflammatory activity of meloxicam gel with diclofenac and piroxicam gel in animals models: pharmacokinetic parameters after topical application. Skin Pharmacol Physiol. 2002;15(2):105-11.

Dumka VK, Dinakaran V, Ranjan B, Rampal S. Comparative pharmacokinetics of cefquinome following intravenous and intramuscular administration in goats. Small Ruminant Res. 2013;113:273- 7.

Sharma HP, Gaur A. Disposition Kinetics of Cefquinome in Calves after a Single Intramuscular Bolus Dose. Int J Curr Microbiol App Sci. 2019;8(1):494-500.

Lina L. Pharmacokinetics of acetyl isovaleryltylosin tartrate in laying hens, Master dissertation, Huazhong Agricultural Univ Coll Vet Med, China, 2008.

Salman AH, Youssef SAH, Ramadan A, Soliman M. Pharmacokinetics of tylvalosin in healthy and experimentally Mycoplasma gallisepticum infected broiler chickens. Int J Pharmatech Res. 2016;9(10):72-80.

Baggot JD. Some aspects of clinical pharmacokinetics in veterinary medicine. J Vet Pharmacol Ther. 1978;1:5-18.

Snedecor GW. Statistical methods. 4th ed. Ames, IA: The Lowa state University Press. 1969: 91.

Patel H, Patel N, Patel S, Dewda S, Patel J, Bhavsar S, Thaker A. Effect of ketoprofen co-administration and febrile State on Pharmacokinetic of cefepime in goats. Asian J Anim Vet. Adv. 2012;7:46-53.

Joly V, Pangon B, Brion N, Vallois J M & Carbon C. Enhancement of the therapeutic effect of cephalosporins in experimental endocarditis by altering their pharmacokinetics with diclofenac. J Pharmacol Exper Therap. 1988;246:695-700.

Patel H, Patel N, Patel S, Dewda S, Patel J, Bhavsar S, Thaker A. Effect of ketoprofen co-administration or febrile state on pharmacokinetic of cefepime in sheep. Vet Arhiv. 2012;82:473-81.

Barot D. Studies on pharmacokinetics of cefpirome in rats and effect of fever and coadministration of ketoprofen on pharmacokinetics of cefpirome along with its safety in goats. Ph.D. Thesis. Anand Agricultural University. Gujarat, India. 2011.

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Published

2020-03-24

How to Cite

El Hanbally, S., Gendy, H. E., Gendy, H. E., Hewaity, M. E., & Hewaity, M. E. (2020). Pharmacokinetics of cefquinome in goats after intramuscular administration alone and with meloxicam. International Journal of Basic & Clinical Pharmacology, 9(4), 518–522. https://doi.org/10.18203/2319-2003.ijbcp20201095

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Original Research Articles