A comparative study of tapentadol versus tramadol in the treatment of low back pain
Keywords:Tramadol, Tapentadol, Pain, VAS, Analgesic
Background: Nontraumatic musculoskeletal disorders are the main reason for presentation to the emergency department with Rachialgia being the most common reason to request medical assessment among them.
Methods: This was a prospective, randomized, parallel group open labelled study conducted in a district level tertiary care hospital attached to a medical teaching institute. Patients were randomized into two groups. Group I (63 patients) received tablet tramadol 50 mg twice daily orally and group II (63 patients) received tablet tapentadol 50 mg twice daily orally.
Results: The mean age of the patients of group I was 40.6±9.6 years and in the group II was 42.7±10.6 years. A total of 61 males participated in the study of which 31 males were enrolled in group I and 30 in group II while 65 females participated in the study of which 32 females were enrolled in group I and 33 in group II. The mean reduction of pain intensity VAS score at the end of 4 weeks from baseline in group I and group II were 34.57 and 37.55 respectively. The difference in the mean reduction of pain intensity VAS between the two groups was not statistically significant.
Conclusions: We conclude that both the drugs show significant reduction in the pain intensity in moderate to severe CLBP patients. Tapentadol is as efficacious as tramadol in moderate to severe CLBP. However, tapentadol is better tolerated than tramadol.
Gureje O, Korff VM, Simon GE, Gater R. Persistent pain and well-being: A World Health Organization Study in Primary Care. JAMA. 1998;280(2):147-51.
Jain D, Basniwal PK. Tapentadol, a novel analgesic: review of recent trends in synthesis, related substances, analytical methods, pharmacodynamics and pharmacokinetics. Bulletin Faculty Pharmacy Cairo University. 2013;51(2):283-9.
Liu L, Skinner M, Donough SM, Mabire L, Baxter GD. Acupuncture for Low Back Pain: An Overview of Systematic Reviews. Evidence Based Complementary Alternative Med. 2015;2015:328196.
Atlas SJ, Deyo RA. Evaluating and Managing Acute Low Back Pain in the Primary Care Setting. J General Internal Med. 2001;16(2):120-31.
Pillastrini P, Gardenghi I, Bonetti F, Capra F, Guccione A, Mugnai R, et al. An updated overview of clinical guidelines for chronic low back pain Management in primary care. Joint Bone Spine. 2012;79(2):176-85.
Kinkade S. Evaluation and treatment of acute low back pain. Am Fam Physician. 2007;75(8):1181.
Ogunbode AM, Adebusoye LA, Alonge TO. Prevalence of low back pain and associated risk factors amongst adult patients presenting to a Nigerian family practice clinic, a hospital-based study. Afr J Prm Health Care Fam Med. 2013;5(1).
Balague F, Mannion AF, Pellise F, Cedraschi C. Non-specific low back pain. Lancet. 2012;379(9814):482-91.
Schug SA. The role of tramadol in current treatment strategies for musculoskeletal pain. Therapeutics Clin Risk Management. 2007;3(5):717-23.
Mannion AF, Balague F, Pellise F, Christine. Pain measurement in patients with low back pain. Nature Clinical Practice Rheumatology. 2007;3:610-8.
Schnitzer TJ, Gray WL, Paster RZ, Kamin M. Efficacy of tramadol in treatment of chronic low back pain. Rheumatol. 2000;27(3):772-8.
Vasani P, Savsani D, Chhaiya S, Mehta D. A Comparative Study of efficacy and safety of tapentadol versus tramadol In Patients of Osteoarthritic Pain and/or Low Back Pain in Orthopedics Department of a Tertiary Care Teaching Hospital. Int J Med Sci Den Health. 2015;1:104-11.
Zaman ZA, Kumar D. Evaluation of analgesic effect of tapentadol, a central novel analgesic versus tramadol, a widely used opioid analgesic in treatment of low back pain: a randomized controlled trial. Int J Basic Clin Pharmacol. 2013;2:392-6.
Ebadi S, Henschke N, Nakhostin AN, Fallah E, Tulder VMW. Therapeutic ultrasound for chronic low-back pain. Cochrane Database Systematic Reviews. 2011;6:1-9.
Weiner SS, Nordin M. Prevention and management of chronic back pain. Bes Practice Res Clin Rheumatology. 2010;24:267-79.