DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20190564

Drug utilization study of antibiotics in infectious diseases in a tertiary care hospital

Kirti Rangdal, Anand Kanaki, Ketan Patil

Abstract


Background: Infectious diseases represent a major cause of mortality and morbidity in India. Irrational use of antibiotics can cause increase adverse drug reaction, leading to antibiotic resistance and increase in the treatment cost. Hence pattern of use of antibiotics need to be studied, therefore the aim of our study is to observe the antibiotics prescription pattern and drug utilization in department of medicine indoor patients at our tertiary care hospital.

Methods: This was a prospective observational study carried out among indoor patients admitted in medicine ward and was conducted between January 2018 to March 2018 in Basaveshwara Teaching and General Hospital attached to M.R. Medical College, Kalaburagi. The data that was obtained was analysed and presented as percentages using descriptive statistics.

Results: 100 patients were enrolled. The main reasons for admission were for diagnosis of respiratory tract infection (36%), GIT disorders (24%), Zoonotic disease (10%), Urinary tract infection (19%) and viral fever (11%). Most common antibiotic prescribed was ceftriaxone (40%), followed by piperacillin (26%). Average number of antibiotics per prescription was 1.7.

Conclusions: For a wide spectrum of clinical diagnoses variety of drugs were utilized from various drug classes. Results showed that Cephalosporin was extensively used. As antibiotics are most commonly prescribed drugs and report of misuse is not uncommon so proper strategy like educational intervention and antibiotic policy are necessary to control this.


Keywords


Antibiotic, Drug utilization, Prescription pattern, Rational use

Full Text:

PDF

References


Srishyla MV, Mahesh K, Nagarani MA, Andrade C, Venkataraman BV. Prescription audit in an Indian hospital setting using the DDD (Defined Daily Dose) concept. Indian J Pharmacol. 1994;26:23‐8.

Ansari KU, Singh S, Pandey RC. Evaluation of prescribing pattern of doctors for rational drug therapy. Indian J Pharmacol. 1998;30(1):43-6.

Melrose D. Double deprivation public and private drug distribution from the perspective of the third world’s poor. World Dev. 1983;11(3):181-6.

Lesar TS, Briceland LL. Survey of antibiotic control policies in university affiliated teaching institutions. Ann Pharmacother. 1996;30:31-4.

Sjoqvist F, Birkett D. Drug utilization. WHO publications. 1975;5:39-50.

Niederman MS. Appropriate use of antimicrobial agents: Challenges and strategies for improvement. Crit Care Med. 2003;31:608.

Brink A, Feldman C, Richards GA, Moolman G, Senekal M. Emergence of extensive drug resistance among gram negative bacilli in South Africa looms nearer. S Afr Med J. 2008;98:586-92.

Safadar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobial resistance Staphylococcus aureus, Enterococcus, Gram negative bacilli, Clostridium difficle and Candida. Ann Intern Med. 2002;136:834-44.

Gama H. Drug utilization studies. Arquivos de Med. 2008;22(2/3):69-74.

John LJ, Devi P, John J, Arifulla M, Guido S. Utilization patterns of central nervous system drugs: A cross sectional study among the critically ill patients. J Neurosci Rural Pract. 2011;2:119-23.

JEJr McGowan. Economic Impact of Antimicrobial Resistance. Emerg Infect Dis. 2001;7:286-92.

Peripi SB, Thadepalli VG, Khagga M. profile of antibiotic consumption, sensitivity and resistance in an urban area of Andhra Pradesh, India. Singapore Med J. 2012;53(4):268-72.

Meher BR, Mukharjee D. Udayshankar. A study on antibiotic utilization pattern in a general medicine ward of a tertiary care teaching hospital. J Chem Pharm Res. 2014;6:1847-9.

Chaudhary KP, Maurya AK. Drug utilization pattern in medicine department in a tertiary care teaching hospital in Uttar Pradesh. Indo Am J Pharm Res. 2015;5(03):1164-69.

Remesh A, Salim S, Gayathri AM. Antibiotics prescribing pattern in the in-patient. Departments of a tertiary care hospital. Arch Pharma Pract. 2013;4:71-6.

Drupad HS, Nagabushan H, Prakash GM. Prospective and observational study of antimicrobial drug utilization in medical intensive care unit in a tertiary care teaching hospital. Int J Pharmacol Res. 2016;6(1):13-7.

Badar VA, Navale SB. Study of prescribing pattern of antimicrobial agents in medicine intensive care unit of a teaching hospital in Central India. JAPI. 2012;60:20-3.

Shankar RP, Partha P, Shenoy NK, Easow JM, Brahmadathan KN. Prescribing patterns of antibiotics and sensitivity patterns of common microorganisms in the Internal Medicine ward of a teaching hospital in Western Nepal: a prospective study Annals Clin Microbiol Antimicrob. 2003;2:7.

WHO. How to investigate drug use in health facilities: selected drug indicators, action program on essential drugs (DAP), Geneva, 1993:12-25. Available at: http://apps.who.int/medicinedocs/en/d/Js2289e/.