Beneficial role of Avocado oil orally used in Osteoarthritis: experience in a tertiary care hospital of Bihar, India

Authors

  • Akash Chandra Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India
  • Anjani Kumar Department of Medicine, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India
  • Manish Kumar Department of Orthopedics, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India
  • Manish Kumar Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India
  • Harihar Dikshit Department of Pharmacology, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20192179

Keywords:

Avocado oil, NSAIDS, Osteoarthritis, Oxford Knee score, Synovial joints, Visual analogue scale

Abstract

Background: Osteoarthritis is the most common type of joint disease. It represents a heterogeneous group of conditions resulting in common histopathologic and radiologic changes. It is a degenerative disorder arising from biochemical breakdown of articular (hyaline) cartilage in the synovial joints.

Methods: Total of 90 patients were randomly selected from outdoor and indoor of Orthopaedics department (IGIMS Patna). Study was done in Department of Pharmacology & Orthopaedics at IGIMS Patna. Three groups A, B and C were taken. Each group was consist of 30 patients of both sexes and age groups between 18 to 65 years. Group A was received Multivitamin with Exercise. Group B was received NSAIDS only. Group C was received Avocado oil orally along with Exercises as Muscle strengthening exercises of Quadriceps, Hamstrings, Abductor and Adductor muscles of thigh. We had compared pain thresholds among all these three groups with the help of Visual analogue scale and Oxford Knee score.

Results: After 3 months of treatment the patients belonging to group C showed better response as compared to group A and B. When we compared pain threshold among group A, B and C on the basis of Oxford Knee score group C had occupied maximum score, which meant satisfactory joint functions and did not require any formal treatment. we also compared average visual analogue scale and average oxford knee score, Group C showed better response.

Conclusions: Avocado oil is a food supplement and does not contain any side effects as compared to NSAIDS [Non-steroidal anti inflammatory drugs], glucosamine sulfate, chondroitin sulfate, sulfasalazine etc so avocado oil can be used for long duration in case of osteoarthritis.

References

Osteoarthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. April 2015. Archived from the original on 18 May 2015. Retrieved 13 May 2015.

Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ. Osteoarthritis. Lancet. 2015;386 (9991):376-87. (PMID 25748615).

Arden N, Blanco F, Cooper C, Guermazi A, Hayashi D, Hunter D, et al. Atlas of Osteoarthritis. Springer; 2015:21. ISBN 978-1-910315-16-3. Archived from the original on 2017-09-08.

Flood J. The role of acetaminophen in the treatment of osteoarthritis. The American Journal of Managed Care. 16 Suppl Management (Suppl Management). March 2010:S48-54. PMID 20297877. Archived from the original on 2015-03-22.

Xie F, Ye H, Zhang Y, Liu X, Lei T, Li S. Extension from inpatients to outpatients: validity and reliability of the Oxford Knee Score in measuring health outcomes in patients with knee osteoarthritis. Int J Rheumatic Diseases. 2011 May;14(2):206-10.

Reips UD, Funke F. Interval-level measurement with visual analogue scales in Internet-based research: VAS Generator. Behavior research methods. 2008 Aug 1;40(3):699-704.

Xie F, Ye H, Zhang Y, Liu X, Lei T, LI SC. Extension from inpatients to outpatients: validity and reliability of the Oxford Knee Score in measuring health outcomes in patients with knee osteoarthritis. Int J Rheumatic Diseases. 2011 May;14(2):206-10.

Dawson J, Fitzpatrick R, Murray D, Carr A. Questionnaire on the perceptions of patients about total knee replacement. J Bone Joint Surgery. British volume. 1998 Jan;80(1):63-9.

Gould D. Visual Analogue Scale (VAS). J Clin Nursing. 2001;10:697-706.

Scott J, Huskisson EC. Graphic representation of pain. Pain. 1976;2:175-84

Unlu NZ, Bohn T, Clinton SK, Schwartz SJ. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J Nutrition. 2005 Mar 1;135(3):431-6.

Morton JF. Avocado; In: Fruits of Warm Climates. Creative Resource Systems, Inc., Winterville, NC and Center for New Crops & Plant Products, Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN. 1987:91-102. (ISBN 0-9610184-1-0).

Dreher ML, Davenport AJ. Hass avocado composition and potential health effects. Critical reviews in food science and nutrition. 2013 Jan 1;53(7):738-50.

Mauviel A, Daireaux M, Hartmann DJ, Galera P, Loyau G, Pujol JP. Effects of unsaponifiable extracts of avocado/soy beans (PIAS) on the production of collagen by cultures of synoviocytes, articular chondrocytes and skin fibroblasts. Rev Rhum Mal Osteoartic. 1989;56(2):207-11. [PubMed].

Boumediene K, Felisaz N, Bogdanowicz P, Galera P, Guillou GB, Pujol JP. Avocado/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes. Arthritis Rheum 1999;42(1):148-56. [PubMed].

Belcher C, Fawthrop F, Bunning R, Doherty M. Plasminogen activators and their inhibitors in synovial fluids from normal, osteoarthritis, and rheumatoid arthritis knees. Ann Rheum Dis. 1996;55(4):230-6. [PubMed].

Heinecke LF, Grzanna MW, Au AY, Mochal CA, Rashmir-Raven A, Frondoza CG. Inhibition of cyclooxygenase-2 expression and prostaglandin E2 production in chondrocytes by avocado soybean unsaponifiables and epigallocatechin gallate.

Downloads

Published

2019-05-23

How to Cite

Chandra, A., Kumar, A., Kumar, M., Kumar, M., & Dikshit, H. (2019). Beneficial role of Avocado oil orally used in Osteoarthritis: experience in a tertiary care hospital of Bihar, India. International Journal of Basic & Clinical Pharmacology, 8(6), 1167–1171. https://doi.org/10.18203/2319-2003.ijbcp20192179

Issue

Section

Original Research Articles