Drug utilization study in dengue infection in a tertiary care hospital
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20190667Keywords:
Dengue fever, Drug utilization pattern, DDD/ATC codeAbstract
Background: Dengue fever (DF) is a serious public health problem, gaining global attention because of its morbidity and mortality. Less studies on Drug utilization pattern of DF in India. The present study was undertaken to analyze Drug utilization pattern of dengue infection in a tertiary care hospital.
Methods: A prospective cross-sectional study was conducted for a period of 2 months in a tertiary care hospital and the data was analyzed by using various drug use indicators.
Results: A total of 52 prescriptions were analyzed. Male and female were (46.16%, 53.84%), A total of 330 drugs were prescribed. 86 (26.06%) antibiotics, 70 (21.21%) antipyretics, 51 (15.46%) antacids, 19 (5.76%) multivitamins, 52 (15.76%) anti-emetics and 52 (15.76%) papaya leaf extract was prescribed. 84 (25.46%) oral and 246 (74.54%) injectable drugs. IV-fluids given to all patients. 10 (19.24%) were given blood transfusion. 6.17 drugs per prescription. 96% drugs were prescribed by brand names. High DDD for drugs like diclofenac (184), doxycycline (115), metronidazole (2.5), pantoprazole (161.5), rabeprazole (34.6), ondansetron (200) was observed.
Conclusions: Most commonly used drugs are antipyretics, antibiotics, antacids, antiemetic, papaya leaf extract. As the incidence of DF is increasing with epidemics, demand for specific treatment guidelines is in great need. Early recognition of the disease, with a rational approach in case management leads good clinical outcome.
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References
Hasan S, Jamdar SF, Alalowi M, Al Ageel Al Beaiji SM. Dengue virus: A global human threat: Review of literature. J Int Soc Prevent Comm Dent. 2016;6(1):1-6.
Hombach J. Vaccines against dengue: a review of current candidate vaccines at advanced development stages. Pan Am J Public Health. 2007;21:254-60.
Gubler DJ. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002 Feb;10(2):100-3.
World Health Organization Dengue: Guidelines for Diagnosis. Treatment, Prevention and Control: New Edition. World Health Organization: Geneva. 2009. Available at: https://www.who.int/rpc/guidelines/9789241547871/en/.
Halstead SB, Suaya JA, Shepard DS. The burden of dengue infection. Lancet. 2007 Apr 28;369(9571):1410-1.
Lam SK, Burke D, Gubler D, Méndez-Gálvan J, Thomas L. Call for a World Dengue Day. Lancet. 2012;379(9814):411-2.
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013 Apr;496(7446):504.
Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG, et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Neglected Trop Dis. 2012 Aug 7;6(8):e1760.
Gupta N, Srivastava S, Jain A, Chaturvedi UC. Dengue in India. Indian J Med Res. 2012;136:373-90.
World Health Organization Dengue and severe dengue. Geneva. 2003. Available at: http://www.who.int/mediacentre/factsheets/fs117/en/.
Simmons CP, Farrar JJ, Nguyen VV, Wills B. Dengue. N Engl J Med. 2012;366:1423-32.
World Health Organization: Introduction to Drug Utilization Research. 2003;1-49. Available at: http://apps.who.int/medicinedocs/pdf/s4876e/s4876e.pdf
Birkett D, Smet PD, Adjei DO, Trolin I, Bergman U, Strom H, et al. Introduction to Drug Utilization Research. WHO. 2003:6-9. Available at: http://www.whocc.no/filearchive/publications/2010guidelines.pdf.
WHO. How to investigate drug use in health facilities: selected drug indicators, action program on essential drugs (DAP), Geneva. 1993:12-25. Available at: http://apps.who.int/medicinedocs/en/d/Js2289e/.
Karande S, Sankhe P, Kulkarni M. Patterns of prescription and drug dispensing. Indian J Pediatr. 2005 Feb 1;72(2):117-21.
WHO Collaborating Centre For Drug Statistics Methodology: ATC index with DDDs 2002.Oslo: World Health Organisation, 2002. Available at: http://www.whocc.no/filearchive/publications/2010guidelines.pdf.
Hafeez AK, Akheel MA, Ashfaque A, Meera NK. Prescribing pattern for the treatment of dengue in a tertiary care hospital, Bangalore-India. Pharma tutor 2011. Available at: https://www.pharmatutor.org/articles/prescribing-pattern-of-treatment-of-dengue-in-tertiary-care-hospital-bangalore https://www.pharmatutor.org/articles/prescribing-pattern-of-treatment-of-dengue-in-tertiary-care-hospital-bangalore.
Rani U, Kamath SG, Varun HV, Aithal S, Patil U. Prescribing Patterns in Dengue Fever in Paediatric Patients in a tertiary care hospital: A retrospective cross sectional study. Int J Pharma Sci Rev Res. 2014;24(2):112-8.
Soegijanto S, Budiyanto, Kartika, Taufik, Amor. The monthly changing of the lowest population dengue virus infection in patient at Soerya hospital. Indonesian J Trop Infect Dis. 2011;2(1):20-24.
Beg MA. Study on Drug Prescribing Pattern in Dengue Patients in a Tertiary Care Hospital –A tool to teach Clinical Pharmacology. J Drug Delivery Therapeut. 2015 Mar 14;5(2):73-6.
Dharmarathna SL, Wickramasinghr S, Waduge RN. Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model. Asian Pac J Trop Biomed. 2013 Sep; 3(9):720-724.
Shalini S, Ravichandran V, Mohanty BK, Dhanraj SK, Saraswati R. Drug utilization studies an overview. Int J Pharmaceut Sci Nanotechnol. 2010;3(1):803-10.
Tabish A, Jha RK, Rathod AM, Rathod RM, Gupta VK, Prescribing trend of analgesics in a tertiary health care setup of rural Vidarbha: A critical appraisal RJPBCS. 2012;3(3):566-71.
Rahman MS, Begum ZA, Samad MK. Prescribing pattern of non-steroidal anti-inflammatory drugs at outpatient departments of teaching hospitals. Bangladesh J Pharmacol. 2007;2(1):1-6.
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