Drug utilization study of antihypertensive drugs in a tertiary care hospital


  • A. R. Radhika Department of Pharmacology, Government Medical College, Mahabubnagar, Telangana, India




Anti hypertensives, Angiotensin receptor blockers, Drug utilization study, Hypertension


Background: Hypertension is a major common disease and effects a million of people worldwide. And is risk factor for other diseases like cardiovascular diseases, stroke etc. The aim of our study was undertaken to study the utilization pattern of anti hypertensive drugs at a tertiary care hospital. The guidelines for the treatment of hypertension are put forward by the Joint National Committee (JNC) on detection, evaluation and treatment of blood pressure. The Indian guidelines endorsed by the cardiology society of India, the hypertension society of India, and Indian college of physicians closely follow the JNC guidelines.

Methods: A prospective cross-sectional observational study was conducted on 100 patients in outpatient Department of General medicine of Government General Hospital, Mahabubnagar district, Telangana. The data collected was analysed from the prescription pattern of anti hypertensive drugs. The data collected were statistically analysed and presented as counts and percentages.

Results: Out of 100 study subjects, males were 55% and females were 45% and maximum number of patients in age group are (51 to 60 years.). Among antihypertensive drugs commonly used in present study are Losartan (ARB’s)-64% and for two drug therapy are enalapril and amlodipine 22% and for three drug therapy are enalapril +atenolol+furosemide-14%. Average number of drugs prescribed is 6.15% per prescription. Percentages of medicines prescribed by generic drugs are85% and from the essential drug list are 95%.

Conclusions: In this study usage of anti hypertensive drugs were prescribed rationally in tertiary care hospital. The study emphasizes that need for effective continuing medical education and also preventive measures in hypertensive individuals.


Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, et al. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertension. 2014 Jun;32(6):1170.

WHO. What is drug utilization research and why it is needed? In: introduction to drug utilization research-World Health Organization; 2003:8-12. Available at: http://apps.who.int/medicinedocs/pdf/s4876e/s4876e.pdf. Accessed 14 May 2016.

WHO. Drug classification systems. In: introduction to drug utilization research-World Health Organization; 2003:33-37. Available at: http://apps.who.int/medicinedocs/pdf/s4876e/s4876e.pdf. Accessed 14 May 2016.

WHO. Drug utilization metrics and their application. In: introduction to drug utilization research-World Health Organization; 2003:38-41. Available at: http://apps.who.int/medicinedocs/pdf/s4876e/s4876e.pdf. Accessed 16 May 2016.

Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002 Dec 4;288(21):2709-16.

Xavier D, Mathew N, Pradeep J, Pais P. Pattern of drug use in hypertension in a tertiary hospital: a cross sectional study in the in-patient wards. Indian J Pharmacol. 2001;33(6):456-7.

Isenalumhe AE, Oviawe O. Polypharmacy: its cost burden and barrier to medical care in a drug-oriented health care system. Int J Health Services. 1988 Apr;18(2):335-42.

Mohd AH, Mateti UV, Konuru V, Parmar MY, Kunduru BR. A study on prescribing patterns of antihypertensives in geriatric patients. Perspectives Clinical Research. 2012 Oct;3(4):139.

Beg MA, Dutta S, Varma A, Kant R, Bawa S, Anjoom M, et al. A study on drug prescribing pattern in hypertensive patients in a tertiary care teaching hospital at Dehradun, Uttarakhand. Int J Med Sci Public Health. 2014 Aug 1;3(8):922-7.

Kaur S, Gupta S, Kumar D, Lal M, Gilani Z. Prescribing pattern of antihypertensive drugs in a tertiary care hospital in Jammu: a descriptive study. JK-Practitioner. 2012 Oct;17(4):38-41.

Keane WF, Anderson S, Aurell M, de Zeeuw D, Narins RG, Povar G. Angiotensin converting enzyme inhibitors and progressive renal insufficiency: current experience and future directions. Ann Internal Med. 1989 Sep 15;111(6):503-16.

Malhotra S, Karan R, Pandhi P, Jain S. Pattern of use and pharmacoeconomic impact of antihypertensive drugs in a north Indian referral hospital. European J Clin Pharmacol. 2001 Sep 1;57(6-7):535-9.

Nakanishi N, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K. Serum uric acid and risk for development of hypertension and impaired fasting glucose or Type II diabetes in Japanese male office workers. European J Epidemiol. 2003 Jun 1;18(6):523-30.

Uusitupa M, Siitonen O, Aro A, Pyörälä K. Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed type 2 (non-insulin-dependent) diabetic subjects. Diabetologia. 1985 Jan 1;28(1):22-7.




How to Cite

Radhika, A. R. (2018). Drug utilization study of antihypertensive drugs in a tertiary care hospital. International Journal of Basic & Clinical Pharmacology, 7(12), 2309–2313. https://doi.org/10.18203/2319-2003.ijbcp20184680



Original Research Articles