Drug utilization pattern of antiepileptic agents among pediatric epilepsy at tertiary care teaching hospital of Gujarat: a cross sectional study

Hirenkumar H. Dave; Niyati A. Trivedi

doi:10.18203/2319-2003.ijbcp20183031

Authors

Hirenkumar H. Dave Department of Pharmacology, Zydus Medical College and Hospital, Dahod, Gujarat, India
Niyati A. Trivedi Department of Pharmacology, Government Medical College, Vadodara, Gujarat, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20183031

Keywords:

Carbamazepine, Cross-sectional study, Epilepsy, Seizures

Abstract

Background: Epilepsy is one of the most common neurological disorders characterized by recurrent episodic paroxysmal involuntary clinical events associated with abnormal electrical activity from the neurons. Without the knowledge of how drugs are being prescribed and used, it is difficult to initiate discussion on rationale drug use and to suggest measures to change prescribing habits for the better management. Present study was performed with an aim to study the utilization pattern of anti-epileptic drugs (AEDs) for the paediatric patients suffering from various forms of epileptic seizures.

Methods: The present cross-sectional study was conducted at the epilepsy clinic of Department of Paediatrics, Tertiary Care Teaching Hospital of Gujarat, on patients diagnosed to have epilepsy July 2014 to October 2014. Hundred Paediatric patients of either gender diagnosed to had epilepsy and taking treatment from pediatric epilepsy clinic OPD, S.S.G. Hospital, and Baroda. Patient’s detailed medical history, demographic details and other required information was recorded on a prestructured data entry form.

Results: Out of 100. GTCS was found to be the most common (55%) form of epilepsy among pediatric patients and Carbamazepine was the most commonly prescribed (41%) AED followed by sodium valproate (38%). 71% patients were prescribed monotherapy. Carbamazepine +Clobazam was the most commonly (7%) used combination.

Conclusions: Use of appropriate AEDs in the majority of patients as per WHO guidelines, has decreased number of ADRs in this study.

Metrics

Metrics Loading ...

References

Grete Soimer. Introduction to drug utilization research Geneva: WHO; 2003:6-9.

Sutharson L, Hariharan RS, Vamsadhara C. Drug utilization study in Diabetology outpatient setting of a tertiary hospital. Indian J. Pharmacol. 2003;35:237-8.

Bakssas I, Lunde PKM. National drug policies: the need for drug utilization studies. Trends Pharmacol Sci. 1986;7:331.

Yuen YH, Chang S, Chong CK, Lee SC, Critchley JA, Chan JC. Drug utilization in hospital general medical outpatient Clinic with particular reference to antihypertensive and antidiabetic drugs. J Clin Pharm Ther. 1998;23:287-94.

Ghai OP, Gupta P, Paul VK. Essential Pediatrics, 8th edition, CBS Publishers and Distributors, New Delhi; 2013:584.

Brunton L, Chabner BA, Knollman B. Goodman and Gilman’s. The pharmacological basics of therapeutics 12th Edition. San Diego, California; 1307-1351.

Megiddo I, Colson A, Chisholm D, Dua T, Nandi A, Laxminarayan R. Health and economic benefits of public financing of epilepsy treatment in India: An agent-based simulation model. Epilepsia. 2016;57(3):464-74.

Dwivedi C. Antiepileptic Drugs. Am J Pharm Educ. 2001;65:197-201.

Stein MA, Kanner AM. Management of newly diagnosed epilepsy. A practical guide to monotherapy. Drugs. 2009;69(2):199-222.

Pahl K, de Boer HM. Atlas: epilepsy care in the world. Geneva: WHO; Epilepsy and rights; 2005:72-73.

Nadkarni J, Uike D, Sharma U, Dwivedi R. Effect of Antiepileptic drugs on lipid profile in children with Epilepsy. Int J Med Res Rev. 2014;2(2):119-23.

Dua T, de Boer HM, Prilipko LL, Saxena S. Epilepsy Care in the World: results of an ILAE/IBE/WHO Global Campaign Against Epilepsy survey. Epilepsia. 2006;47(7):1225-31.

Hasan SS, Bahari MB, Babar ZU, Ganesan V. Antiepileptic drug utilisation and seizure outcome among paediatric patients in a Malaysian public hospital. Singapore Med J. 2010;51(1):21-7.

Kousalya K, Cherukuri SDP, Padmasani LN, Arun Prasath TS. Drug utilization pattern of antiepileptics and their adverse effects in pediatrics. World J Pharmaceuti Resear. 2014;3(9):504-513.

Mistry RA, Solanki KC, Prajapati HK, Doshi TM, Trivedi HR. Drug utilization pattern of antiseizure drugs and their adverse effects in the pediatric population, in a tertiary care hospital attached to a medical college Jamnagar. Int J Basic Clin Pharmacol. 2014;3(2):336-442.

World Health Organization (WHO). Primary prevention of mental, neurological, psychological disorder. Geneva: WHO Press, World Health Organization (Online); 1998. Available at: http://www.who.int/mental_health/evidence/en/prevention_of_mental_disorders_sr.pdf. Accessed on 31st Jan, 2015.

Krumholz A, Wiebe S, Gronseth G, Shinar S, Levisohn P, Ting T, et al. Evaluating an apparent unprovoked first seizure in adults (an evidence-based review): report of the quality standards subcommittee of the American academy of neurology and the American epilepsy society. Neurology. 2007;69:1996-2007.

Sandeep A, Chandra SD, Chand BT, Saravaran S, Kumar SRT. Study of Drug utilization, Cost effectiveness and outcome of antiepileptics used in pediatric ward of tertiary care hospital in tamilnadu, India. Int J Pharmaceu Res Schola. 2013;2(4):409-502.

Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis and management of epilepsy in children and young people - A national clinical guideline; March 2005. Available at: http://www.sign.ac.uk/pdf/sign81.pdf. Accessed on 31st Jan 2015.