Analgesic activity of Cissus quadrangularis linn with Zingiber officinale rosc in male wistar rats


  • Santosh Kumar Department of Pharmacology, Kerala Medical College and hospital, Mangode, Palakkad, Kerala, India
  • Chakrapani Cheekavolu Department of Pharmacology, Kerala Medical College and hospital, Mangode, Palakkad, Kerala, India
  • P. Leela Department of Biochemistry, SVIMS, Tirupati, Andhra Pradesh, India
  • Simhadri V. S. D. N. A. Nagesh Department of Pharmacology, Tagore Medical College & Hospital, Chennai, Tamil Nadu, India
  • M. Naresh Kumar Department of Biochemistry, Sri Patanjali Maharshi Naturopathy& Yoga Medical College, Guntakal, Andhra Pradesh, India
  • N. Jagan Department of Pharmacology, Texila American University, Georgetown, Guyana, South America



Analgesic, Cissus quadrangularis Linn, Hotplate, Zingiberofficinale Rosc


Background: The global scenario, human beings are using various forms of treatment for relief of pain; among them, medicinal plant products have gained popularity because of its wide range of use and less side effects.

Methods: Adult Albino rats of either sex were selected and divided into 5 groups. The Eddy’s hot plate was used and maintained temperature (55±0.5ºC), the animals were placed on the hot plate and the time taken for paw licking or jumping was recorded and considered as nociceptive response. The reaction time was observed on 0, 30, 60, and 90 minute.

Results: The hot plate reaction time in sec was collected in the intervals of 0, 30, 60 and 90 minutes in all groups. Reaction times as follows: group III (Cissus quadrangularis Linn.) were 2.18±0.04, 3.13±0.05**, 5.83±0.05**, 5.39±0.04**;  Group IV (Zingiber officinale Rosc.) were 2.12±0.03, 4.13±0.04**, 7.43±0.07**, 7.16±0.06**; Group V Cissus quadrangularis Linn+ Zingiber officinale Rosc.) were 2.21±0.75, 4.67±0.98**, 8.15±0.89**, 9.02±0.75**; Group II (Dexamethasone) were 2.14±0.05, 5.53±0.05**, 8.14±0.06**, 10.08±0.10** respectively, Results are presented as mean±SEM, (n=6), *p<0.01, **p<0.05 dunnet test used as compared to control.

Conclusions: Present study reveals that, the combination treatment of Zingiber officinale Rosc. + Cissus quadrangularis Linn. has been shown significant analgesic effect. High analgesic effect was observed with combination therapy; the effect was shown same as standard drug dexamethasone.


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How to Cite

Kumar, S., Cheekavolu, C., Leela, P., Nagesh, S. V. S. D. N. A., Kumar, M. N., & Jagan, N. (2017). Analgesic activity of Cissus quadrangularis linn with Zingiber officinale rosc in male wistar rats. International Journal of Basic & Clinical Pharmacology, 6(10), 2496–2499.



Original Research Articles