Evaluation of anticonvulsant activity of amlodipine in albino rats


  • Roopa B. Department of Pharmacology, RVM Institute of Medical Sciences and Research Centre, Laxmakkapally, Mugulu, Medak, Telangana, India
  • Janardhan M. Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences, Adilabad, Telangana, India
  • Venkata Rao Y. Department of Pharmacology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India




Amlodipine, Anticonvulsant, Maximal electroshock seizures, Phenytoin


Background: The objective of the study was to evaluate the anticonvulsant activity of amlodipine in albino rats.

Methods: Anticonvulsant activity of amlodipine was done in three graded doses (1 mg/kg, 2 mg/kg, 4 mg/kg), and combination group with low dose of amlodipine (1 mg/kg) and standard drug (phenytoin) in maximal electroshock seizures (MES) experimental animal model.

Results: Amlodipine in dose of 2, 4 mg/kg showed dose dependent significant anticonvulsant effect and combination of low dose amlodipine and low dose of standard drug also showed significant anticonvulsant effect in MES model.

Conclusions: Amlodipine is having anticonvulsant activity and also potentiated the anticonvulsant effect of phenytoin in MES model.



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How to Cite

B., R., M., J., & Y., V. R. (2017). Evaluation of anticonvulsant activity of amlodipine in albino rats. International Journal of Basic & Clinical Pharmacology, 6(3), 664–668. https://doi.org/10.18203/2319-2003.ijbcp20170833



Original Research Articles