Evaluation of anticonvulsant activity of amlodipine in albino rats

Roopa B.; Janardhan M.; Venkata Rao Y.

doi:10.18203/2319-2003.ijbcp20170833

Authors

Roopa B. Department of Pharmacology, RVM Institute of Medical Sciences and Research Centre, Laxmakkapally, Mugulu, Medak, Telangana, India
Janardhan M. Department of Pharmacology, Rajiv Gandhi Institute of Medical Sciences, Adilabad, Telangana, India
Venkata Rao Y. Department of Pharmacology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda, Telangana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20170833

Keywords:

Amlodipine, Anticonvulsant, Maximal electroshock seizures, Phenytoin

Abstract

Background: The objective of the study was to evaluate the anticonvulsant activity of amlodipine in albino rats.

Methods: Anticonvulsant activity of amlodipine was done in three graded doses (1 mg/kg, 2 mg/kg, 4 mg/kg), and combination group with low dose of amlodipine (1 mg/kg) and standard drug (phenytoin) in maximal electroshock seizures (MES) experimental animal model.

Results: Amlodipine in dose of 2, 4 mg/kg showed dose dependent significant anticonvulsant effect and combination of low dose amlodipine and low dose of standard drug also showed significant anticonvulsant effect in MES model.

Conclusions: Amlodipine is having anticonvulsant activity and also potentiated the anticonvulsant effect of phenytoin in MES model.

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