Lamotrigine-induced fulminant hepatic failure: an unusual presentation

M. C. Gupta, J. Khanna, R. Mathur, N. Mittal


Lamotrigine (LTG) is indicated for the management of seizures either alone or in combination with other anticonvulsant agents. Adverse effects with it are usually mild. Less than 1% of subjects show deranged liver function tests during long therapy. Fulminant hepatic failure with LTG is an unusual presentation. We report a fatal case of hepatic failure with LTG monotherapy in a 22-year-old male patient suffering from a seizure disorder. Cases of LTG induced hepatotoxicity should be carefully monitored, particularly serious case of fulminant hepatic failure which should be adequately assessed and reported to determine their exact incidence.


Lamotrigine, Hepatic failure

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