Prospective single blind placebo-controlled randomized clinical trial to assess the efficacy and safety of metformin in promoting wound healing and weight reduction in non-diabetic overweight post-operative female patients


  • C. Meenal Department of Obstetrics and Gynecology, Sri Venkateshwaraa Medical College Hospital and Research Center, Ariyur, Pondicherry, India Department of Obstetrics and Gynecology, Manipal Medical College, Maleka, Malaysia
  • Revathy Saravanan Department of Pharmacology, Sri Venkateshwaraa Medical College and Research Center, Ariyrur, Pondicherry, India


Metformin, Wound healing, Weight reduction, Non-diabetic overweight post-operative female patients


Background: Obesity is an important preventable risk factor that can affect wound healing. Oral hypoglycemic drug metformin apart from its antihyperglycemic and not hypoglycemic property has been reported to promote wound healing in non-diabetic animal studies and weight reduction in non-diabetic individuals. Hence, this: prospective randomized study single-blind placebo-controlled study was designed with the aim to assess the efficacy and safety of metformin in wound healing and weight reduction in a tertiary care hospital in Pondicherry during the period between December 2012 and January 2014.

Methods: 215 non-diabetic post-operative patients with body mass index (BMI) of 25-29.9 kg/m2 from the Department of Obstetrics and Gynecology included after obtaining informed consent received tablet metformin 500 mg or placebo B.D from 2nd post-operative day up-to 30 days. Fasting blood sugar, postprandial blood sugar, BMI were recorded initially, and at the end. Clinical evaluation of wound was done on 8th, 15th and 30th post-operative days. Unpaired t-test was applied to compare the two groups for quantitative analysis and Chi-square test to analyze the qualitative outcome by using GraphPad prism - 6 software. p<0.05 was considered to be statistically significant.

Results: Surgical site infection of 13.3% and 3.3% was observed in control and metformin groups respectively. Wound healing promoting effect of metformin was evidenced by p=0.0087 and 0.01 on 8th and on 15th day. Weight reducing effect was evidenced by p=0.0001 on comparing BMI. No significant hypoglycemia was observed. No adverse drug reaction was reported.

Conclusions: Our study has shown metformin having best wound healing and weight reducing effect without producing hypoglycemia. Long-term studies on all types of surgeries in both males and females including emergencies are suggested.


Rashid M, Wai-Ping LF, Guul S, Enoch S. How to undertake research in wound healing. Wounds UK. 2009;5(3):76-85.

Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219-29.

NIH. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. Bethesda (MD): National Institutes of Health; 1998. Downloaded 16 September 2012.

Biondo-Simões Mde L, Zammar GR, Fernandes Rdos S, Biondo-Simões R, Mello FS, Noronha Ld Obesity and abdominal wound healing in rats. Acta Cir Bras. 2010;25(1):86-92.

Kalra S, Unnikrishnan AG. Obesity in India weight of the nation. J Nutr Neutroceuticals. 2012;1(1):36-41. Available at http// Downloaded 24 November 2012.

OECD. Obesity Update – 2012. Available at Accessed 25 November 2014.

Rock JA, Jones HW. Incisions for gynaecological surgery. Telinde’s Operative Gynaecology. 10th Edition. Philadelphia: Lippincott Williams & Williams; 2008: 246-79.

Rao Bandaru N, Rangarao A, Vijayanadaprasad K, Ramamoorthy DVS. A prospective study of post-operative wound infections in a teaching hospital of rural setup. J Clin Diagn Res. 2012;6 Suppl 7:1266-71.

Tan JT, Coleman K, Norris S, Mapari J, Shastri S, Metz L. Surgical site infection in India: a systematic review of the incidence and economic burden. Jhonson and Johnson medical Asia pacific. Available at http:/ Accessed 22 May 2014.

Ambrish C, Torgal SS, Patil PA, Malur PR, Hiremath SV. Influence of oral anti-diabetic agents on wound healing in euglycemic male wistar rats. Pharmacol Online. 2009;1:476-83.

Levri KM, Allen Last ES, Yeh J, Ference J, Amico FD, Wilson SA. Metformin as treatment for overweight and obese adults: a systematic review. Ann Fam Med 2005;3(5):457-61. Available at

Schuster D, Gaillard T, Rhinesmith S, Habash D, Osei K. Impact of metformin on glucose metabolism in non-diabetic, obese African Americans: a placebo-controlled, 24-month randomized study. Diabetes Care. 2004;27(11):2768-9.

Available at http://www.Clinical Downloaded 05 March 2013.

Davis SN. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. Goodman & Gilman’s: the Pharmacological Basis of Therapeutics. 11th Edition. New York: McGraw-Hill; 2006.

Harvey RA, Champe PC, Mycek MJ. Insulin and oral hypoglycaemic drugs. In: Harvey RA, Champe PC, Mycek MJ, editors. Pharmacology. Hagerstown, Maryland: Lippincott Williams & Wilkins; 1996. pp. 261.

Bhadauria AR, Hariharan C. Clinical study of post-operative wound infections in obstetrics and gynaecological surgeries in a tertiary care set up. Int J Reprod Contracept Obstetr Gynecol. 2013;2(4):631-8.

Saxena A, Singh MP, Brahmchari S, Banerjee M. Surgical site infection among postoperative patients of tertiary care centre in Central India-a prospective study. Asian J Biomed Pharm Sci. 2013;3(17):41-4.

Praharaj SK, Jana AK, Goyal N, Sinha VK. Metformin for olanzapine-induced weight gain: a systematic review and meta-analysis. Br J Clin Pharmacol. 2011;71(3):377-82.

Björkhem-Bergman L, Asplund AB, Lindh JD. Metformin for weight reduction in non-diabetic patients on antipsychotic drugs: a systematic review and meta-analysis. J Psychopharmacol. 2011;25(3):299-305.




How to Cite

Meenal, C., & Saravanan, R. (2017). Prospective single blind placebo-controlled randomized clinical trial to assess the efficacy and safety of metformin in promoting wound healing and weight reduction in non-diabetic overweight post-operative female patients. International Journal of Basic & Clinical Pharmacology, 4(2), 363–370. Retrieved from



Original Research Articles