Knowledge, attitude, and practice among healthcare professionals of adverse drug reactions reporting in a tertiary care center
Keywords:
Pharmacovigilance, Safety signals, Under-reportingAbstract
Background: There has been a rapid increase in the number of drugs entering the market from last few decades. Preclinical and clinical data are insufficient to conclude the complete safety of drugs. Hence, it is necessary to have a robust pharmacovigilance system in place to generate safety signals. Under reporting of adverse drug reactions (ADRs) exists as an inherent weakness of current voluntary reporting scheme. This study was therefore taken up, to evaluate the knowledge, attitude, and practice about ADR reporting among doctors in a tertiary care center.
Methods: The present study was a cross-sectional questionnaire-based study, which included prescribers of a tertiary care teaching hospital. We tried to find out the possible ways to improve reporting of ADR and factors responsible for deficient reporting of ADRs.
Results: After analyzing the data, we observed that 59% of the responders were aware of the ADRs reporting system. And the most encouraging finding was 94% of the respondents think that this reporting system is necessary. However, the practice was very poor just 14% among the respondents. 74% and 61% of participants felt creating awareness among healthcare professionals, and training to healthcare professionals would lead to improvement in reporting of ADRs respectively. Main factors which discouraged ADR reporting by healthcare professionals were reporting would lead to extra work 70.5%, non-availability of forms 64.5%.
Conclusion: The deficiencies in ADR reporting require attention so as to improve spontaneous reporting and enhance safety of patients.
Metrics
References
Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008;42(7):1017-25.
Rehan HS, Vasudev K, Tripathi CD. Adverse drug reaction monitoring: knowledge, attitude and practices of medical students and prescribers. Natl Med J India. 2002;15(1):24-6.
World Health Organization. The importance of pharmacovigillance. Safety Monitoring of Medicinal Products. Essential Medicines and Health Products Information Portal. Geneva: WHO; 2002: 1-52.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239-45.
John LJ, Mohamad A. Reporting of ADR: an exploratory study among nurses in a technical hospital. Ajman, United Arab Emirates. Daru J Pharm Sci. 2012;20(44):2-6.
Desai CK, Iyer G, Panchal J, Shah S, Dikshit RK. An evaluation of knowledge, attitude, and practice of adverse drug reaction reporting among prescribers at a tertiary care hospital. Perspect Clin Res. 2011;2(4):129-36.
Lee KK, Chan TY, Raymond K, Critchley JA. Pharmacists’ attitudes toward adverse drug reaction reporting in Hong Kong. Ann Pharmacother. 1994;28(12):1400-3.
Aziz Z, Siang TC, Badarudin NS. Reporting of adverse drug reactions: predictors of under-reporting in Malaysia. Pharmacoepidemiol Drug Saf. 2007;16(2):223-8.
Herdeiro MT, Figueiras A, Polónia J, Gestal-Otero JJ. Physicians’ attitudes and adverse drug reaction reporting: a case-control study in Portugal. Drug Saf. 2005;28:825-33.
Thomas TM, Udaykumar P. Knowledge attitude and practice of adverse drug reaction reporting among doctors in a tertiary centre in South India. Int J Pharmacol Clin Sci. 2013;2:82-8.
Kharkar M, Bowalekar S. Knowledge, attitude and perception/practices (KAP) of medical practitioners in India towards adverse drug reaction (ADR) reporting. Perspect Clin Res. 2012;3(3):90-4.
Chatterjee S, Lyle N, Ghosh S. A survey of the knowledge, attitude and practice of adverse drug reaction reporting by clinicians in eastern India. Drug Saf. 2006;29:641-2.
Agarwal R, Daher AM, Mohd Ismail N. Knowledge, practices and attitudes towards adverse drug reaction reporting by private practitioners from Klang valley in Malaysia. Malays J Med Sci. 2013;20(2):52-61.
Fadare J, Okezie EO. Knowledge attitude and practice of adverse drug reaction reporting among healthcare workers in a tertiary centre in Northern Nigeria. Pharmacoepidemiol Drug Saf. 2008;17:517-22.
Rajesh R, Vidyasagar S. An educational intervention to asses’ knowledge attitude practice of pharmacovigilance among healthcare professionals in an Indian tertiary care teaching hospital. Int J Pharma Tech Res. 2011;3(2):678-92.
Santosh KC, Tragulpiankit P, Gorsanan S, Edwards IR. Attitudes among healthcare professionals to the reporting of adverse drug reactions in Nepal. BMC Pharmacol Toxicol. 2013;14:16.
Mishra H, Kumar V. Pharmacovigilance: current scenario in a tertiary care teaching medical college in North India. J Pharmacovigil. 2013;1(2):2-4.
