Drug utilization study in genitourinary infections used as a teaching tool for rational therapy for MBBS students in a Medical College at Dehradun, Uttarakhand

Shakti B. Dutta, Mirza A. Beg, Shalu Bawa, Amanjot Kaur


Background: There is a need to introduce clinical pharmacology at the undergraduate level in order to improve rational prescribing of medicines. The present study was undertaken to analyze drug utilization pattern of genitourinary infections to teach certain basic skills to MBBS students which will form an integral component of practicing rational therapeutics.

Methods: The retrospective study was conducted by Pharmacology Department in Shri Guru Ram Rai Institute of Medical and Health Sciences (SGRRIM and HS). A total of 92 prescriptions were collected by second professional MBBS students and randomly evaluated for prescribing pattern using WHO drug indicators.

Results: A total of 92 prescriptions were analyzed. Male:female ratio was 1.96:1. Age wise distribution was done: 0-15 years were 14 (15.21%), 16-30 years were 26 (28.26%), 31-45 years were 24 (26.08%), 46-60 years were 19 (20.65%), and >60 years were 9 (9.78%). A total of 260 drugs were prescribed. 116 (44.61%) antimicrobials, 70 (26.92%) antacids and antiemetics, 40 (15.38%) analgesics, 11 (4.23%) urinary alkalizers, 9 (3.23%) antifibrinolytics, and 14 (5.38%) miscellaneous drugs were prescribed. 144 (55.38%) injectable and 116 (44.61%) oral drugs were prescribed. Numbers of fixed-dose combinations were 32 (34.78%). 2.82 drugs per prescription were prescribed. 171 (65.76%) drugs were prescribed from National List of Essential Medicines 2013 (NLEM 2013). Majority of drugs were prescribed by brand names.

Conclusion: Majority of drugs were prescribed from NLEM 2013. The main purpose of undergraduate medical curriculum is to develop the requisite diagnostic and therapeutic skills of a basic doctor. It is only by drug utilization studies that burden of diseases and corresponding utilization of drugs can be measured.


Genitourinary infections, Fixed dose combinations, Drug utilization studies

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Gitanjali B, Shashindran CH. Curriculum in clinical pharmacology for medical undergraduates of India. Indian J Pharmacol. 2006;38:108-14.

Introduction to drug utilization research by World Health Organization. Available from: http://www.whocc.no/filearchive/publication/drug_utilization_research.pdf. Accessed 05 October 2014.

Stamm WE, Hooton TM. Management of urinary tract infections in adults. N Engl J Med. 1993;329(18):1328-34.

Om PS, Ranjana D, Jagat K, Gulam MK, Santosh M, Badri P, et al. Prescribing and sensitivity patterns of antimicrobials in uncomplicated urinary tract infections in females. J Drug Deliv Ther. 2014;4(2):1-8.

World Health Organization (WHO) and International Network for Rational Use of Drugs, How to Investigate Drug Use in Health Facilities: Selected Drug Use indicators. WHO/DAP/93.1, Geneva, Switzerland: WHO; 1993.

Lee D, Bergman U. Studies of drug utilization. In: Storm LB, editor. Pharmacoepidemiology. Chichester, UK: Johnn Wiley & Sons; 2005: 401-17.

Muraraiah S, Sarda A, Romana A, Jayanthi CR. Prescribing pattern in paediatric urinary tract infections at a tertiary care centre. J Chem Pharm Res. 2012;4(6):3201-6.

Prakasam KC, Kumar KG, Vijayan M. A cross sectional study on distribution of urinary tract infection and their antibiotic utilisation pattern in Kerala. Int J Res Pharm Biomed Sci. 2012;3(3):1125-30.

Akter T, Mia Z, Shahriar M. Antibiotic sensitivity of pathogens causing urinary tract infection. Bangladesh Pharm J. 2013;16(1):53-8.

Kaushal S, Chopra SC, Arora S. Modifications in the undergraduate MBBS pharmacology practical curriculum: the DMCH model. Indian J Pharmacol. 2007;39(1):57-9.

Loeb M, Brazil K, Lohfeld L, McGeer A, Simor A, Stevenson K, et al. Effect of a multifaceted intervention on number of antimicrobial prescriptions for suspected urinary tract infections in residents of nursing homes: cluster randomised controlled trial. BMJ. 2005;331(7518):669.

Scottish Intercollegiate Guidelines Network (SIGN). Management of Suspected Bacterial Urinary Tract Infection in Adults. A National Clinical Guideline. Edinburgh: SIGN Publication; 2006.

Hummers-Pradier E, Kochen MM. Dysuria. DEGAM-guideline No. 1. Z Allgemeinmed. 2000;76:35-48.

Ramanath KV, Shafiya SB. Prescription pattern of antibiotic usage for urinary tract infection treated in a rural tertiary care hospital. Indian J Pharm Pract. 2011;4(2):57-63.

Bleidorn J, Gágyor I, Kochen MM, Wegscheider K, Hummers-Pradier E. Symptomatic treatment (ibuprofen) or antibiotics (ciprofloxacin) for uncomplicated urinary tract infection? – results of a randomized controlled pilot trial. BMC Med. 2010;8:30.

Matute AJ, Hak E, Schurink CA, McArthur A, Alonso E, Paniagua M, et al. Resistance of uropathogens in symptomatic urinary tract infections in León, Nicaragua. Int J Antimicrob Agents. 2004;23:506-9.

Hariharan TS. Need for changes in practical pharmacology curriculum of medical undergraduates. Indian J Pharmacol. 2004;36(3):181.

Mathur VS. Towards a more meaningful teaching of pharmacology. Indian J Pharmacol. 2004;36(4):259-61.