Vorapaxar, a novel oral antiplatelet drug


  • Kranti Tekulapally Department of Pharmacology, Malla Reddy Medical College for Women, Hyderabad, India


Vorapaxar, Protease activated receptor 1 antagonsit, Thrombin receptor antagonist


Vorapaxor is first in the class of protease activated receptor 1 (PAR 1) antagonists. It acts by inhibiting the binding of thrombin to PAR 1 and thereby prevents platelet aggregation. USFDA approved it in May 2014 as the results of clinical trials showed that the benefit: risk ratio was high. It is to be used in a dose of 2.5 mg once daily as triple antiplatelet therapy with aspirin and clopidogrel for reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction or peripheral arterial disease. Increase in the incidence of intracranial hemorrhage is the major side-effect seen.


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How to Cite

Tekulapally, K. (2017). Vorapaxar, a novel oral antiplatelet drug. International Journal of Basic & Clinical Pharmacology, 4(1), 188–190. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/892



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