Maculopapular skin rash due to amoxicillin tri-hydrate hypersensitivity reaction: a case report

Walli Mohammed, Sushanta Kr. Das, Shardha Srikanth, V. Uma Maheswara Rao


Amoxicillin tri-hydrate (AMT) is a commonly used penicillin group of antibacterial agent to combat various bacterial infections. Penicillin group of drugs are known to cause cutaneous drug eruptions as a hypersensitivity reaction. Most of the time, these eruptions are mild in nature, however, sometimes they represent the early manifestation of rare and severe drug-induced cutaneous reactions, such as; Stevens–Johnson syndrome and toxic epidermal necrolysis. Here, we report a case of maculopapular skin rash developed due to AMT hypersensitivity reaction in a 48-year-old Indian male patient. Pheniramine maleate, hydrocortisone and skin protecting lotion were prescribed to manage the situation. This case is being reported to emphasize the need for reporting of drug induced complications and their management procedures.


Amoxicillin tri-hydrate, Hypersensitivity reaction, Maculopapular skin rash, Pheniramine maleate, Hydrocortisone

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