A comparative study of efficacy and safety of pitavastatin versus atorvastatin in the patients of dyslipidemia in medicine department of a tertiary care teaching hospital


  • Punita Vasani Department of Pharmacology, Gujarat Adani Institute of Medical Sciences, Bhuj-Kutch, Gujarat, India
  • Durgesh Savsani Medical Reviewer, TCS, Vikroli, Mumbai, Maharashtra, India
  • Dimple Mehta Department of Pharmacology, C.U. Shah Medical College, Gujarat, India
  • Preeti Bhatt Department of Pharmacology, C.U. Shah Medical College, Gujarat, India
  • Sandip Solanki Department of Pharmacology, C.U. Shah Medical College, Gujarat, India


Dyslipidemia, Atorvastatin, Pitavastatin


Background: Cardiovascular diseases (CVDs) are the major cause of death globally. Dyslipidemia is one of the most significant risk factors for CVD. 3-hydroxy 3-methyl glutaryl coenzyme A reductase inhibitors (statins), which are used for the treatment of dyslipidemia, has a beneficial effect in both primary and secondary prevention of CVD. Hence, this study was done to compare the efficacy and safety of atorvastatin versus pitavastatin in patients of dyslipidemias.

Methods: After obtaining ethical clearance from institution and written informed consent from patients, 100 patients included in the study were randomly allocated to any of the following two groups. (1) Group A: Tablet atorvastatin 10 mg given orally once a day for 12 weeks. (2) Group B: Tablet pitavastatin 2 mg given orally once a day for 12 weeks. The primary endpoint of the study was a comparative assessment of change in lipid profile (triglyceride, low-density lipoprotein [LDL], high-density lipoprotein [HDL]) from baseline and after 12 weeks. The secondary endpoint involved recording all the adverse effects during the study.

Results: Analysis of the baseline and post 12 weeks lipid levels by non-parametric unpaired t-test showed a statistically significant increase in HDL-cholesterol (HDL-C) in Group B as compared to Group A (p=0.028 i.e. p<0.05). However, there was no significant difference between two groups in decreasing LDL-cholesterol (LDL-C) (p=0.615).

Conclusions: In this study, pitavastatin is found to be more efficacious than atorvastatin in increasing HDL-C levels, while as efficacious as atorvastatin in decreasing LDL-C in dyslipidemic patients. Atorvastatin is better tolerated than pitavastatin.


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How to Cite

Vasani, P., Savsani, D., Mehta, D., Bhatt, P., & Solanki, S. (2017). A comparative study of efficacy and safety of pitavastatin versus atorvastatin in the patients of dyslipidemia in medicine department of a tertiary care teaching hospital. International Journal of Basic & Clinical Pharmacology, 4(1), 24–29. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/858



Original Research Articles