Ketorolac eye drop induced allergic wheal and chemosis

H. Mohan Kumar, H. G. Kavya, R. Shubha


Ketorolac is a non-steroidal anti-inflammatory drug which is prescribed rampantly in the treatment of seasonal allergic conjunctivitis due to its clinical efficacy of providing rapid relief from symptoms of allergy. There is a potential for cross sensitivity to aspirin. Hence, a leading question on aspirin allergy must be taken before prescribing the drug ketorolac.


Ketorolac, Aspirin allergy, Allergic wheal

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La Rosa M, Lionetti E, Reibaldi M, Russo A, Longo A, Leonardi S, et al. Allergic conjunctivitis: a comprehensive review of the literature. Ital J Pediatr. 2013;39:18.

Abelson MB, Schaefer K. Conjunctivitis of allergic origin: immunologic mechanisms and current approaches to therapy. Surv Ophthalmol. 1993;38 Suppl:115-32.

Dehar N, Gupta A, Singh G. Comparative study of the ocular efficacy and safety of diclofenac sodium (0.1%) ophthalmic solution with that of ketorolac tromethamine (0.5%) ophthalmic solution in patients with acute seasonal allergic conjunctivitis. Int J Appl Basic Med Res. 2012;2(1):25-30.

Yaylali V, Demirlenk I, Tatlipinar S, Ozbay D, Esme A, Yildirim C, et al. Comparative study of 0.1% olopatadine hydrochloride and 0.5% ketorolac tromethamine in the treatment of seasonal allergic conjunctivitis. Acta Ophthalmol Scand. 2003;81(4):378-82.

Woodward DF, Nieves AL, Hawley SB, Joseph R, Merlino GF, Spada CS. The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. J Ocul Pharmacol Ther. 1995;11(3):339-47.

Berdy GJ, Abelson MB, George MA, Smith LM, Giovanoni RL. Allergic conjunctivitis: a survey of new antihistamines. J Ocul Pharmacol. 1991;7(4):313-24.

Raizman MB. Results of a survey of patients with ocular allergy treated with topical ketorolac tromethamine. Clin Ther. 1995;17(5):882-90.

Ballas Z, Blumenthal M, Tinkelman DG, Kriz R, Rupp G. Clinical evaluation of ketorolac tromethamine 0.5% ophthalmic solution for the treatment of seasonal allergic conjunctivitis. Surv Ophthalmol. 1993;38 Suppl:141-8.

Leonardi A, Busato F, Fregona I, Plebani M, Secchi AG. Anti-inflammatory and antiallergic effects of ketorolac tromethamine in the conjunctival provocation model. Br J Ophthalmol. 2000;84(11):1228-32.

Risser A, Donovan D, Heintzman J, Page T. NSAID prescribing precautions. Am Fam Physician. 2009;80:1371-8.

Stevenson DD, Sanchez-Borges M, Szczeklik A. Classification of allergic and pseudoallergic reactions to drugs that inhibit cyclooxygenase enzymes. Ann Allergy Asthma Immunol. 2001;87(3):177-80.