A prospective study on sleep disorders related to antidepressant drugs use in a tertiary care teaching hospital

Farhan Ahmad Khan; Kirti Vishwakarma; Vishal P. Giri; Chitrak Bansal

doi:10.18203/2319-2003.ijbcp20150392

Authors

Farhan Ahmad Khan Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India
Kirti Vishwakarma Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India
Vishal P. Giri Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India
Chitrak Bansal Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20150392

Keywords:

Sleep disturbances, Antidepressants, Mirtazapine

Abstract

Background: Prescription of antidepressants has been increased from the last decade and responsible for producing sleep disorders as adverse drug reactions (ADRs). Sleep disorders can be divided into 3 large groups: (1) insomnia, (2) primary complaint of daytime sleepiness, and (3) Association of disruptive behaviours during sleep, the disorders of arousal. So active surveillance is needed to access these ADRs.

Aims and Objective: To analyze the sleep disturbances as ADRs of various antidepressants prescribed to the patients attending psychiatry outpatient department (OPD).

Methods: This prospective study was conducted on patients aged ≤74 years attending Department of Psychiatry OPD and were prescribed Antidepressants for the duration of 8 months (December, 2013-July, 2014). The ADRs reported were confirmed by WHO UMC Causality Assessment Scale.

Results: Total number of patients enrolled on the basis of inclusion and exclusion criteria (n=50). Total number of ADRs related to drugs prescribed were found to be n=69. Total number of patients with sleep disturbances as ADRs were found to be n=28.

Conclusion: The drug, most frequently implicated to cause sleep disturbances, was mirtazapine. Increased sleep was the most common ADR, found to occur. Unusual ADRs such as sleep talking was also seen.

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