Anticonvulsant activity of nitrendipine in albino mice
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20150390Keywords:
Anticonvulsant, Nitrendipine, Maximal electroshock, PentylenetetrazoleAbstract
Background: The objective is to evaluate the anticonvulsant activity of nitrendipine in seizure-induced mice.
Methods: Albino mice (25-30 g) of either sex were randomly selected and divided into four groups of six mice each. After overnight fasting, Group I received 0.25 ml of propylene glycol and served as the control, Group II received valproic acid (110 mg/kg orally) as standard, Groups III received 5 mg/kg of nitrendipine and 100 mg/kg of valproic acid, Group IV received 5 mg/kg of nitrendipine and 75 mg/kg of valproic acid, and Group V received 5 mg/kg of nitrendipine and 50 mg/kg of valproic acid all of which were administered orally 60 mins prior to the test in this acute study. The anticonvulsant activity was screened using maximal electroshock (MES) model and pentylenetetrazole (PTZ) model.
Results: The nitrendipine showed a considerable reduction in the duration of hindlimb extensor phase in MES model and also delayed the latency of seizures induced by PTZ when compared with control group. The probable mechanism of anticonvulsant action of nitrendipine could be due to its interference with the gamma amino butyric acid type aminergic mechanism, modulation of nicotinic, and N-methyl-D-aspartate receptors.
Conclusion: Nitrendipine possesses the anticonvulsant activity and has a beneficial role in epilepsy.
References
Lowenstein DH. Seizures and epilepsy. In: Fauci AS, Brainwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al., editors. Harrisons Principles of Internal Medicine. 17th Edition. USA: McGraw Hill; 2008: 2498.
Porter RJ, Meldrum BS. Antiseizure drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th Edition. New Delhi: Tata McGraw Hill; 2009: 399.
McNamara JO. Drugs effective in the treatment of epilepsies. In: Hardman JG, Limbird JE, Molioff PB, Ruddon RW, Gillman AG, editors. Goodman and Gillman’s The Pharmacological Basis of Therapeutics. 12th Edition. New York: McGraw Hill; 2012: 583-6.
Jayaram R, Anitha T, Joshi VD. Analgesic and anticonvulsant effects of Acorus calamus roots in mice. Int J Pharm Tech Res. 2010;2(1):552-5.
Venkataraman S, Gorthi SP. Recent advances in the management of refractory epilepsy. Neurosci Today. 2003;7:183-8.
Desai CK, Dikshit RK, Mansuri SM, Shah UH. Comparative evaluation of anticonvulsant activity of calcium channel blockers in experimental animals. Indian J Exp Biol. 1995;33(12):931-4.
Vogel HG. Anticonvulsant activity. In: Vogel WH, Scholkens BA, Sandow J, Muller G, Vogel WF, editors. Drug Discovery and Evaluation of Pharmacological Assays. 2nd Edition. New York: Springler; 2002: 423-87.
Pooja S, Kannapan N, Anupama D, Parveen K. Anticonvulsant activity of flower part of N. oderum. Int J Pharm Bio Sci. 2010;1(2):1-4.
Sonavane GS, Palehar RC, Kasture SB, Kasture VS. Anticonvulsant and behavioural actions of Myristica fragrans seeds. Indian J Pharmacol. 2002;34(5):332-8.
Shirish Ambavade D, Veena Kasture S, Sanjay Kasture B. Anticonvulsant activity of roots and rhizomes of Glycyrrhiza glabra. Indian J Pharmacol. 2002;34(4):332-8.
Raza M, Alghasham AA, Alorainy MS, El-Hadiyah TM. Potentiation of valproate-induced anticonvulsant response by nigella sativa seed constituents: the role of GABA receptors. Int J Health Sci (Qassim). 2008;2(1):15-25.
Suresh Babu AR, Karki SS. Anticonvulsant activity of various extracts of leaves of nitrendipinenlinn against seizure induced models. Int J Pharm Pharm Sci. 2011;3(3):200-3.
De Sarro GB, Meldrum BS, Nistico G. Anticonvulsant effects of some calcium entry blockersin DBA/2 mice. Br J Pharmacol. 1988;93(2):247-56.
