DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20150364

Cure of human immunodeficiency virus/acquired immune deficiency syndrome: promising future prospects at horizon

Sagar Shashikant Panchal, Prasad R. Pandit, Abhishek M. Phatak, Madhura S. Naik, Komal M. Lohi

Abstract


Acquired immune deficiency syndrome (AIDS) is a disease caused by human
immunodeficiency virus and characterized by profound immunosuppression that
leads to opportunistic infections, secondary neoplasms, and neurologic complications.
AIDS is among the leading causes of death worldwide. Current therapeutic options
are directed only toward management of AIDS, but not toward its prevention or cure.
In addition, it also possesses numerous problems like drug resistance, drug toxicity,
drug interactions, non-adherence to therapy, life-long and expensive treatment, etc.
Recent years in drug development have shown promising prospects for prevention/
treatment/cure of AIDS like histone deacetylase inhibitors, Vpu ion channel inhibitors,
viral decay acceleration, maturation inhibitors, tat antagonists, gene/stem cell therapy,
and antiretroviral vaccines.


Keywords


Antiretroviral therapy, Belinostat, Bevirimat, Valproic acid, National Acquired Immune Deficiency Syndrome Control Organization, Targeted therapies

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