Published: 2017-01-18

Anti-diabetic and hypolipidemic effects of the aqueous leaf extract of Bougainvillea species

Manali Mangesh Mahajan, Sujata Dudhgaonkar, Swapnil Narayan Deshmukh


Diabetes mellitus (DM) is a chronic, metabolic disorder characterized by altered carbohydrate, fat and protein metabolism and an increased risk of micro and macrovascular complications. It is projected to become one of the world’s main disablers and killers within the next 25 years.


Diabetes mellitus, Bougainvillea glabra, Hypoglycemic

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Vuksan V, Sievenpiper JL, Xu Z, Wong EY, Jenkins AL, Beljan-Zdravkovic U, et al. Konjac-Mannan and American ginsing: Emerging alternative therapies for type 2 diabetes mellitus. J Am Coll Nutr. 2001;20 5 Suppl:370S-80.

Al-Waili N. Intrapulmonary Administration of natural honey solution, hyperosmolar dextrose or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: Their effects on blood glucose level, plasma insulin and C-peptide, blood pressure and peaked expiratory flow rate. Eur J Med Res. 2003;8(7):295 303.

Fasanmade AF, Alabi OT. Differential effect of honey on selected variables in alloxan-induced and fructose-induced diabetic rats. Afr J Biomed Res. 2008;11:189-94.

Said O, Fulder S, Khalil K, Azaizeh H, Kassis E, Saad B. Maintaining a physiological blood glucose level with ‘glucolevel’, a combination of four anti-diabetes plants used in the traditional Arab herbal medicine. Evid Based Complement Alternat Med. 2008;5(4):421-8.

Narayanan CR, Joshi DD, Mudjumdar AM, Dhekne VV. Pinitol, a new anti-diabetic compound from the leaves of Bougainvillea spectabilis. Curr Sci. 1987;56:139-41.

Bates SH, Jones RB, Bailey CJ. Insulin-like effect of pinitol. Br J Pharmacol. 2000;130(8):1944-8.

Holman GD, Kasuga M. From receptor to transporter: Insulin signalling to glucose transport. Diabetologia. 1997;40(9):991-1003.

Poongothai G, Sripathi SK. A review on insulinomimetic pinitol from plants. Int J Pharm Bio Sci. 2013;4(2):992 1009.

Edwin E, Sheeja E, Toppo E, Tiwari V, Dutt KR. Antidiarrheal, antiulcer and antimicrobial activities of leaves of Bougainvillea glabra Choisy. Agric Recruit Sci Pharm. 2007;48:135-44.

Adebayo GL, Alabi OT, Owoyele BV, Soladoye AO. Anti-diabetic properties of the aqueous leaf extract of Bougainvillea glabra glory of the garden on alloxan-induced diabetic rats. Rec Nat Prod. 2009;3(4):187-92.