Reversible isolated thrombocytopenia: a rare adverse effect of diclofenac infusion

Divya G. Krishnan; Anukesh V. Keloth; Mohammed Faiz Akram

doi:10.18203/2319-2003.ijbcp20150018

Authors

Divya G. Krishnan Department of Pharmacology, KMCT Medical College, Calicut, Kerala, India
Anukesh V. Keloth Department of Surgery, KMCT Medical College, Calicut, Kerala, India
Mohammed Faiz Akram Department of Pharmacology, KMCT Medical College, Calicut, Kerala, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20150018

Keywords:

Adverse effect, Isolated thrombocytopenia, Reversible, Diclofenac infusion

Abstract

Diclofenac infusion is prescribed for acute painful and inflammatory conditions in intensive care. Thrombocytopenia is a very rare adverse effect of diclofenac infusion. We report a case of thrombocytopenia due to diclofenac infusion, occurring in a 32-year-old male treated conservatively for acute appendicitis. The thrombocytopenia recovered completely with the discontinuation of the drug. The rarity, clinical importance, and the diagnostic difficulty associated with this case prompted us to report it here.

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References

Kim HL, Kovacs MJ. Diclofenac-associated thrombocytopenia and neutropenia. Ann Pharmacother. 1995;29(7-8):713-5.

Bondeson J, Berglund S. Diclofenac-induced thrombocytopenic purpura with renal and hepatic involvement. J Intern Med. 1991;230(6):543-7.

Chhabra R, Ramasharan L, Pathare AV, Shah AS, Jijina F, Badakere SS. Diclofenac induced thrombocytopenia. Indian J Hematol Blood Transfus. 1999;17(3):70-1.

Kenney B, Stack G. Drug-induced thrombocytopenia. Arch Pathol Lab Med. 2009;133(2):309-14.

Aster RH, Bougie DW. Drug-induced immune thrombocytopenia. N Engl J Med. 2007;357:580-7.

Bougie D, Aster R. Immune thrombocytopenia resulting from sensitivity to metabolites of naproxen and acetaminophen. Blood. 2001;97(12):3846-50.

George JN, Raskob GE, Shah SR, Rizvi MA, Hamilton SA, Osborne S, et al. Drug-induced thrombocytopenia: a systematic review of published case reports. Ann Intern Med. 1998;129(11):886-90.

Visentin GP, Liu CY. Drug-induced thrombocytopenia. Hematol Oncol Clin North Am. 2007;21(4):685-96.