Fixed dose combination of ibuprofen and paracetamol induced toxic epidermal necrolysis

Rati Ranjan Debbarma; Manju Gari; Praveen Kumar Sinha; Sabyasachi Mandal

doi:10.18203/2319-2003.ijbcp20164150

Authors

Rati Ranjan Debbarma Department Pharmacology and Therapeutics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Manju Gari Department Pharmacology and Therapeutics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Praveen Kumar Sinha Department Pharmacology and Therapeutics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Sabyasachi Mandal Department Pharmacology and Therapeutics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20164150

Keywords:

FDC, Ibuprofen, OTC drug, Paracetamol, TEN

Abstract

Toxic Epidermal Necrolysis (TEN) is a serious dermatological disorder and a potential life threatening condition, which can be due to drugs or infections. Fixed dose combination (FDC) of Ibuprofen plus Paracetamol is commonly used as an analgesic and antipyretic over the counter (OTC) in India. We present a case of Toxic Epidermal Necrolysis due to Fixed Drug Combination of Ibuprofen and Paracetamol. Awareness should be there both at the level the consumers and the health care professionals regarding occurrence of such rare but potentially serious side effect associated with such combination.

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