DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20171092

Effect of anti-epileptic drugs on cognitive functions: a prospective study in individuals with newly diagnosed complex partial seizure and generalized tonic clonic seizure

Jayant Rai, Preeti P. Yadav, Richa Verma, Mayur Chaudhari

Abstract


Background: Epilepsy, the third most common neurologic disorder, deteriorates cognitive functions of the patients. Approximately 1% of the world’s population is suffering from epilepsy. Opinions regarding impact of anti-epileptic drugs on cognition are divided. So, this study was designed to assess the impact of anti-epileptic drugs on cognitive performance of patients with complex partial seizure and generalized tonic clonic seizure in Department of Medicine, at Government Medical College, Surat, Gujarat, India.

Methods: In present study, cognitive functions were assessed in 50 patients of newly diagnosed complex partial seizure and generalized tonic clonic seizure coming to the Department of Medicine, Surat. The cognitive functions were evaluated by Addenbrooke’s Cognitive Examination (ACE)-III, which assessed memory, attention, fluency, language and visuo-spatial abilities. Follow-up was done after six months of baseline.

Results: Baseline and Follow-up data from 50 patients were analysed. Patient treated with anti-epileptic drugs showed significant improvement in memory, attention, language and visuo-spatial abilities whereas improvement in fluency was not significant. Paired t-test and Wilcoxon Signed Ranks Test were used to analyse the data. For statistical analysis of data SPSS 19.0 software was used.

Conclusions: The available data indicate that the anti-epileptic drugs on short-term administration do not adversely affect cognitive function in patients with newly diagnosed CPS and GTCS. Importantly, the data suggest that the effects exerted by AEDs could depend on factors linked to patient characteristics and individual susceptibility and to comment on those factors further studies are needed.


Keywords


Addenbrooke’s cognitive examination-III, Anti-epileptic drugs, CPS, Cognition, Epilepsy, GTCS

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References


Guyton AC, Hall JE. The Nervous System: motor and integrative neurophysiology. 16th ed: Elsevier; 2016.

Rang HP, Ritter JM, Flower RJ, Henderson G. In Rang & Dale's Pharmacology. Antiepileptic Drugs. 7 ed: Elsevier; 2012.

Lowenstein DH. In Harrison's Principles of Internal Medicine. Seizures and epilepsy. 19th ed. McGraw Hill; 2015.

Hanai T. Quality of life in children with epilepsy. Epilepsia. 1996;37:28-32.

Trimble MR, Krishnamoorthy ES. Neuropsychiatric disorders in epilepsy: some transcultural issues. Epilepsia. 2003;44:21-4.

Trimble MR. Anti-epileptic drugs, cognitive function and behavior in children: evidence from recent studies. Epilepsia. 1990;31:S30-4.

Donati F, Gobbi G, Campistol J, Rapatz G, Daehler M, Sturm Y et al. The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures. Seizure. 2007;16(8):670-9.

Hessen E, Lossius MI, Reinvang I, Gjerstad L. Influence of major antiepileptic drugs on attention, reaction time, and speed of information processing: results from a randomized, double-blind, placebo-controlled withdrawal study of seizure-free epilepsy patients receiving monotherapy. Epilepsia. 2006;47(12):2038-45.

Dam M, Ekberg R, Loyning Y, Waltimo O, Jakobsen K. A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy. Epilepsy Res. 1989;3(1):70-6.

Tromp SC, Weber JW, Aldenkamp AP, Arends J, vander Linden I, Diepman L. Relative influence of epileptic seizures and of epilepsy syndrome on cognitive function. J Child Neurol. 2003;18(6):407-12.

Aldenkamp AP. Effect of seizures and epileptiform discharges on cognitive function. Epilepsia. 1997;38:s52-s5.