Sociodemographic profile of Helicobacter pylori positive functional dyspepsia patients in central India
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20150022Keywords:
Dyspepsia, Functional dyspepsia, Helicobacter pylori, C-14 urea breath testAbstract
Background: Dyspepsia is one of the common complaints in all sectors of the Indian population. It is diagnosed in the presence of symptoms thought to originate from gastroduodenal region and if there is no organic cause to explain dyspeptic symptoms on upper gastrointestinal endoscopy, the patient is labeled as functional dyspepsia (FD). Helicobacter pylori, a Gram-negative bacilli harboring in the acidic gastric environment has been said to be the causative agent, but this association has not been proved in Indian population. Hence, this study was conducted to find out the prevalence of H. pylori in FD.
Methods: After the approval from Institutional Ethics Committee, patients presenting with symptoms of dyspepsia of both sex, within age group of 18-60 years and any dietary habit were enrolled in the study. After a detailed history and complete general and systemic examination, patients were subjected to gastroduodenoscopy. On endoscopy, if no lesion was observed, then the patient was labeled as FD. The severity of dyspepsia symptoms was assessed by seven-point global overall symptom (GOS) scale. Patients were then screened for H. pylori infection by both invasive (rapid urease, Gram staining, and culture) and non-invasive tests (C-14 urea breath test).
Results: The prevalence of H. pylori in FD was found to be 63.38%. Among 90 H. pylori positive FD patients, 56% were male, 58.89% were below the age of 40 years, and 53.33% belonged to middle income group. The average GOS score for dyspepsia symptoms was 6.01±0.64. Epigastric pain and mild gastritis were the most common presenting symptom and endoscopic finding, respectively.
Conclusion: Our results suggest that H. pylori is an important causative factor for dyspeptic symptoms in patients of FD. Hence, all the FD patients must be investigated for H. pylori and treated promptly.
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References
Talley NJ, Vakil N. Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol. 2005;100:2324-37.
Hammer J, Talley NJ. Nonulcer dyspepsia. Curr Opin Gastroenterol. 1999;15(6):492.
Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol. 2005;3(6):543-52.
Tack J, Bisschops R, Sarnelli G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology. 2004;127(4):1239-55.
Czesnikiewicz-Guzik M, Karczewska E, Bielanski W, Guzik TJ, Kapera P, Targosz A, et al. Association of the presence of Helicobacter pylori in the oral cavity and in the stomach. J Physiol Pharmacol. 2004;55 Suppl 2:105-15.
Kullavanijaya P, Thong-Ngam D, Hanvivatvong O, Nunthapisud P, Tangkijvanich P, Suwanagool P. Analysis of eight different methods for the detection of Helicobacter pylori infection in patients with dyspepsia. J Gastroenterol Hepatol. 2004;19(12):1392-6.
Armstrong D. Helicobacter pylori infection and dyspepsia. Scand J Gastroenterol Suppl. 1996;215:38-47.
Locke CR rd, Talley NJ, Nelson DK, Haruma K, Weaver AL, Zinsmeister AR, et al. Helicobacter pylori and dyspepsia: a population-based study of the organism and host. Am J Gastroenterol. 2000;95(8):1906-13.
McColl K, Murray L, El-Omar E, Dickson A, El-Nujumi A, Wirz A, et al. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med. 1998;339(26):1869-74.
Veldhuyzen van Zanten SJ, Chiba N, Armstrong D, Barkun AN, Thomson AB, Mann V, et al. Validation of a 7-point global overall symptom scale to measure the severity of dyspepsia symptoms in clinical trials. Aliment Pharmacol Ther. 2006;23(4):521-9.
Goodwin CS, Armstrong JA, Chilvers T. Transfer of Campylobacter pylori and Campylobacter mutstelae to Helicobacter gen. nov. as Helicobacter pylori comb. Nov. and Helicobacter mutstelae comb. nov respectively. Int J Syst Bacteriol. 1989;39:397-405.
Berry V, Sagar V. Rapid urease test to diagnose Helicobacter pylori infection. JK Sci. 2006;8:86-8.
Ayyagari A, Ray P, Kochhar R, Bhasin D, Siddeshi ER, Singh K, et al. Evaluation of different methods for detection of Helicobacter pylori in patients with gastric disease. Indian J Med Res. 1990;91:126-8.
McNulty CA, Dent JC. Rapid identification of Campylobacter pylori (C. pyloridis) by preformed enzymes. J Clin Microbiol. 1987;25(9):1683-6.
Hegedus O, Rydén J, Rehnberg AS, Nilsson S, Hellström PM. Validated accuracy of a novel urea breath test for rapid Helicobacter pylori detection and in-office analysis. Eur J Gastroenterol Hepatol. 2002;14(15):513-20.
Shaib Y, El-Serag HB. The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States. Am J Gastroenterol. 2004;99(11):2210-6.
Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut. 1999;45 Suppl 2:II37-42.
Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000;22(2):283-97.
Bosques-Padilla FJ, Tijerina-Menchaca R, Pérez-Pérez GI, Flores-Gutiérrez JP, Garza-González E. Comparison of Helicobacter pylori prevalence in symptomatic patients in northeastern Mexico with the rest of the country: its association with gastrointestinal disease. Arch Med Res. 2003;34(1):60-3.
Singh V, Trikha B, Nain CK, Singh K, Vaiphei K. Epidemiology of Helicobacter pylori and peptic ulcer in India. J Gastroenterol Hepatol. 2002;17(6):659-65.
Gill HH, Desai HG, Majmudar P, Mehta PR, Prabhu SR. Epidemiology of Helicobacter pylori: the Indian scenario. Indian J Gastroenterol. 1993;12(1):9-11.
Kumar R, Bano G, Kapoor B, Sharma S, Gupta Y. Clinical profile in H. pylori positive patients in Jammu. JK Sci. 2006;8(3):148-50.
Auriemma L, Signorelli S. The role of tetracycline in the retreatment after Helicobacter pylori eradication failure. Minerva Med. 2001;92(3):145-9.
Shah SS, Bhatia SJ, Mistry FP. Epidemiology of dyspepsia in the general population in Mumbai. Indian J Gastroenterol. 2001;20(3):103-6.
Malaty HM, Graham DY. Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection. Gut. 1994;35(6):742-5.
