Published: 2017-03-25

A prospective study to evaluate oral iron preparations in antenatal women at a tertiary care hospital

Satyanarayana V., Shabeer D., Suma Jayaram, Basavaraj Bhandare


Background: Iron deficiency is the most common cause of anemia in pregnancy worldwide. It can be mild, moderate or severe. Severe anemia can have very serious consequences for mothers and babies. Pregnant women requiring medication represent a challenge to healthcare providers to avoid any teratogenic risk to foetus. The purpose of this study was to provide information about the most effective iron preparations prescribed to pregnant women and to evaluate the haemoglobin status before and after oral iron therapy.

Methods: This was a Prospective observational study conducted in the Department of Obstetrics and Gynaecology, Rajarajeswari Medical College and Hospital, between October 2013 and March 2014.This study was conducted by reviewing the antenatal care Outpatient department case papers of 200 pregnant women who were anaemic.

Results: Demographic profile, detailed medical history and drug intake in current pregnancy was noted. The prescription pattern was assessed. Of the three common iron preparations prescribed, Ferrous sulphate was the most common preparation. Findings of our study showed that all pregnant anaemic women included in the study were provided with iron and folic acid therapy and the most effective oral iron preparation was Ferrous sulphate.

Conclusions: Present study shows that ferrous sulphate is the most common iron preparation prescribed. Ferrous sulphate and ferrous fumarate preparations showed better improvement in Hb levels. Anaemia is common among all pregnant women and therefore it raises the concern about high morbidity and mortality associated with pregnancy outcome. This can be minimized by educating pregnant women about importance of balanced diet and utilization of antenatal facilities even during early pregnancy.



Drug utilizalion, Ferrous-sulphate, Iron preparations, Pregnant women

Full Text:



World Health Organization. Prevention and management of severe anemia in pregnancy. Report of a Technical Working Group, Geneva. 20-22 May I991. Maternal health and safe motherhood programme, Geneva: WHO; 1993.

Hallberg L. Iron balance in pregnancy and lactation. In: Fomon SJ. Zlotkin S. (Eds). Nutritional anemias, New York: Raven Press; 1992:13-25.

World Health Organization. Daily iron and folic acid supplementation during pregnancy. Available from: As accessed on 14/04/14.

Auerbach M, Goodnough LT, Picard D, Maniatis A. The role of intravenous iron in anemia management and transfusion avoidance. Transfusion. 2008;48:988-1000.

Letsky EA. Anemia. In: James DK, Steer PJ, Weiner CP. Gonik B. editors. High risk pregnancy management options. 2nd ed. London: WB Saunders; I999:729-47.

Levine H, Pollit E, Galloway R, Mcguire J. Micronutrients deficiency disorders. In: Jamison D. Mosley H. Mesham A, Bobdilla JL. (Eds). Disease control priorities in developing countries. New York: Oxford University press; 1993:1042.

World Health Organization. Report of a WHO Group of Experts on Nutritional Anemias, Technical Report Series No. 503, Geneva WHO; I972.

Gama H. Drug utilization studies. Arquivos De Medicina. 2008;22(2/3):69-74.

De Jong LT, Van den Berg PB, Peters PW, Haaijer-Ruskamp FM. A study of drug utilization during pregnancy in the light of known risks. Int J Risk Saf Med. 1990;1(2):91-105.

Mitchell AA1, Gilboa SM, Werler MM, Kelley KE, Louik C, Hernández-Díaz S. Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008. Am J Obstet Gynecol. 2011;205(1):51.e1-8.

Chanarin I, Rotman D. Further observations on the relation between iron and folate status in pregnancy. British Med J. 1971;2:81-4.

Satyanarayana P, Manaswi C, Kalyani P. Oral iron therapy in anaemic and non anaemic pregnant women. Int J Scientific Res Publications. 2014;4(3).

Osungbade KO, Oladunjoye AO. Preventive treatments of iron deficiency anaemia in pregnancy: a review of their effectiveness and implications for health system strengthening. J pregnancy. 2012;2012.

Saha L, Pandhi P, Gopalan S, Malhotra S, Saha P. Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anemia in pregnant women. Med Gen Med. 2007;9(1):1.