DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20150019

Evaluation of antihyperglycemic and hypolipidemic activity of ethanolic extract of Clerodendrum infortunatum Linn. in experimental animals

Yasmeen A. Maniyar, C. R. Roopa, C. H. Janaki Devi

Abstract


Background: Diabetes mellitus (DM) is the most common non-communicable disease of the modern world. The study of plants having antihyperglycemic and hypolipidemic activities may give a new approach in the treatment of DM. The study was intended to evaluate the antihyperglycemic and hypolipidemic activity of ethanolic extract of Clerodendrum infortunatum Linn. (EECL) in alloxan-induced diabetic albino rats.

Methods: Diabetes was induced in albino rats by administration of alloxan monohydrate (160 mg/kg, intraperitoneal). Rats were divided into six groups of six animals each. First group served as non-diabetic control, second group as diabetic control, third group as standard and was treated with 0.1 mg/kg/day of glibenclamide. Group 4, 5, and 6 received 200 and 400 mg/kg body weight of EECL. Blood samples were analyzed for blood glucose on day 1, 3, 7, 14, 21, and 28 and lipid profile on day 28.

Results: The EECL showed a significant reduction (p<0.001) in blood glucose level and serum lipid profile levels with 400 mg/kg body weight in alloxan induced diabetic rats as compared with control.

Conclusion: It is concluded that EECL is effective in controlling blood glucose levels and in improving lipid profile in diabetic rats.


Keywords


Ethanolic extract, Hypoglycemia, Hypolipidemia, Clerodendrum infortunatum Linn

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