DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20150014

Zincovit syrup ameliorates oxidative stress induced by carbon tetrachloride in rats

S. M. Satyam, K. L. Bairy

Abstract


Background: Zincovit (ZVT) syrup is a combined formulation of vitamins, minerals and lysine. The present study was aimed to investigate the in vivo antioxidant potential of ZVT syrup in carbon tetrachloride (CCl4) intoxicated Wistar rats.

Methods: A total of 36 Wistar rats were divided into six groups of six rats each. Antioxidant potential of ZVT syrup at the dose of 15 mg/kg/day, 30 mg/kg/day and 60 mg/kg/day was evaluated in CCl4 intoxicated rats. The extent of CCl4 induced oxidative stress was studied by estimating malondialdehyde (MDA), glutathione-S-transferase (GST) and catalase (CAT).

Results: Oral treatment with ZVT syrup, especially at the dose of 30 mg/kg/day and 60 mg/kg/day reversed CCl4 - induced alterations in MDA (p<0.05), GST (p<0.01) and CAT (p<0.01) compared to CCl4 intoxicated control (untreated) animals.

Conclusion: The present findings revealed that ZVT syrup may be useful in oxidative stress associated tissue damage as a nutritional food supplement.


Keywords


Zincovit syrup, Lysine, Zinc, Oxidative stress, Antioxidant, Carbon tetrachloride

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References


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