Wound healing activity of topical phenytoin in excision wound model of Albino rats

Usha N. S.; Sirisha G.

doi:10.18203/2319-2003.ijbcp20164146

Authors

Usha N. S. Department of Pharmacology, MVJ Medical College and Research Hospital, Hoskote, Bangalore, India
Sirisha G. Department of Pharmacology, Nizam’s Institute of Medical sciences, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20164146

Keywords:

Excision wound, Hydroxyproline, Phenytoin, Wound healing

Abstract

Background: Wound healing is a major medical entity. Phenytoin being an anticonvulsant drug has shown promising results in healing chronic wounds. In the present study we have evaluated the effect of topical Phenytoin on excision wound models of albino rats.

Methods: Phenytoin ointment of 1%, 5% and 10% were used topically on experimental animals. Neomycin used as reference standard. In Excision wound model period of epithelialization, area of wound and hydroxyproline content were evaluated.

Results: Phenytoin 1%, 5% and 10% have shown significant (P<0.001) wound healing property compared to control and Neomycin. Phenytoin hastened the wound healing compared to control and neomycin and increased hydroxyproline content of wound. Phenytoin 5% has better wound healing property compared to 1% and 10%.

Conclusions: The present study has shown that Phenytoin reduces time for wound healing and improved the quality of healing tissue which provides rationale for use in chronic wound in clinical setting.

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