DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20151377

Seizure in a patient on Wellbutrin: a case report

Samreen Ahmed, Saima Warraich

Abstract


We are reporting the case of drug-induced seizure in a 32-year-old Hispanic female who was taking wellbutrin for major depression. Our patient was taking 300 mg/day of wellbutrin when she had one episode of generalized seizure. Wellbutrin uses, side effects, and contraindications are discussed in this case report. Moreover, the factors that make individuals more vulnerable to seizures, as a side effect of wellbutrin, are also highlighted. Interestingly, wellbutrin also has addiction potential hence its abuse is becoming increasingly common that makes it crucial for the clinicians to rule out any history of substance abuse before prescribing it. Literature review has shown a reported case of seizure as a side effect of wellbutrin. Our patient remained seizure free after wellbutrin was discontinued making it the possible cause for her seizure episode.


Keywords


Wellbutrin, Seizure, Major depression

Full Text:

PDF

References


Jiloha RC. Pharmacotherapy of smoking cessation. Indian J Psychiatry. 2014;56(1):87-95.

Demler TL. Drug-induced neurologic condition. US Pharm. 2014;39(1):47-52.

Davidson J. Seizures and bupropion: a review. J Clin Psychiatry. 1989;50(7):256-61.

Bipeta R, Yerramilli SS. Bupropion for the treatment of fluoxetine non-responsive trichotillomania: a case report. J Med Case Rep. 2011;5:557.

Berigan TR. Possible sexual dysfunction associated with bupropion for smoking cessation: a case report. Prim Care Companion J Clin Psychiatry. 1999;1(6):193.

Patterson RN, Herity NA. Acute myocardial infarction following bupropion (Zyban). QJM. 2002;95(1):58-9.

Bailey J, Waters S. Acute psychosis after bupropion treatment in a healthy 28-year-old woman. J Am Board Fam Med. 2008;21(3):244-5.

Thorpe EL, Pizon AF, Lynch MJ, Boyer J. Bupropion induced serotonin syndrome: a case report. J Med Toxicol. 2010;6(2):168-71.

Giasson-Gariépy K, Jutras-Aswad D. A case of hypomania during nicotine cessation treatment with bupropion. Addict Sci Clin Pract. 2013;8:22.

Wah MF, Wah LS. Generalized seizure in a Mauritian woman taking bupropion. PLoS Med. 2004;1(1):e15.

Mufti MA, Holtzheimer PE 3rd, Epstein CM, Quinn SC, Vito N, McDonald WM. Bupropion decreases resting motor threshold: a case report. Brain Stimul. 2010;3(3):177 80.

Humayun F, Shehab TM, Tworek JA, Fontana RJ. A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: case report. J Med Case Rep. 2007;1:88.

McCormick J. Recreational bupropion abuse in a teenager. Br J Clin Pharmacol. 2002;53(2):214.

Aguilera S, Salado C, Díaz López I, Montiano JI, Botella MP. Generalized epileptic seizures in an infant due to passive exposure to cocaine. An Sist Sanit Navar. 2009;32(3):453-6.