Leukopenia in a patient on haloperidol decanoate: a case report
DOI:
https://doi.org/10.18203/2319-2003.ijbcp20151374Keywords:
Diabetes, Haloperidol, Leukopenia, Dry foot gangreneAbstract
We are reporting a case of leukopenia developed in a patient on haloperidol decanoate injections. A literature review revealed it as an uncommon side effect of antipsychotics; however, regular monitoring of blood cell count is crucial in patients on antipsychotics. In this case report, we discussed the effective doses, side effects, and drug interactions of haloperidol decanoate. Neuroleptic malignant syndrome is a rare but serious side effect of haloperidol.
References
Gibson C, Berliner N. How we evaluate and treat neutropenia in adults. Blood. 2014;124(8):1251-8.
Ibáñez L, Vidal X, Ballarín E, Laporte JR. Population-based drug-induced agranulocytosis. Arch Intern Med. 2005;165(8):869-74.
Haloperidol RX. Medscape. Available at http://www.reference.medscape.com/drug/haldol decanoate-haloperidol-342974. Accessed 06 October 2015.
Kane JM, Davis JM, Schooler N, Marder S, Casey D, Brauzer B, et al. A multidose study of haloperidol decanoate in the maintenance treatment of schizophrenia. Am J Psychiatry. 2002;159(4):554-60.
Bhattacharya A, Roy D, Hazarika S, Das S, Nath K, Saddichha S. Alopecia areata associated with haloperidol decanoate long-acting injection. Aust N Z J Psychiatry. 2012;46(1):69.
Karre PR, Gujral J, Rodriguez E. Rhabdomyolysis with erratic serum creatinin phosphokinase levels: intramuscular injection of haloperidol decanoate. BMJ Case Rep. 2009;2009:Bcr06.2009.1931.
Zou D, Shao Y, Qin Z, Zhang J, Liu N, Li Z, et al. Death due to fulminant neuroleptic malignant syndrome induced by low doses of haloperidol: a rare case. J Forensic Leg Med. 2014;24:12-4.
Colvard MD, Gentry JD, Mullis DM. Neurotoxicity with combined use of lithium and haloperidol decanoate. Prim Care Companion CNS Disord. 2013;15(6):PCC.13l01563.
Hsu ST, Hsu CH, Chang CJ. Acute pulmonary edema and transient leukopenia in haloperidol-induced neuroleptic malignant syndrome. Crit Care. 1998;2(1):155.
