To study the efficacy and safety of Vitamin D as an add-on therapy in patients of Type 2 diabetes mellitus on oral antidiabetic drugs

Ravneet K. Sandhu; Geeta Sharma; Satya B. Nayyar; Meenakshi Gupta

doi:10.18203/2319-2003.ijbcp20151372

Authors

Ravneet K. Sandhu Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India
Geeta Sharma Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India
Satya B. Nayyar Department of Medicine, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India
Meenakshi Gupta Department of Pharmacology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20151372

Keywords:

Diabetes mellitus, Vitamin D deficiency, Vitamin D

Abstract

Background: Predominance of Type 2 diabetes mellitus (DM) is increasing globally at an alarming rate. Therapies for Type 2 DM have improved but still there is a need for new insights to limit the progression of the disease. Vitamin D deficiency has been associated with many non-skeletal disorders including Type 2 DM, suggesting a role in pathogenesis of Type 2 DM. Therefore, the present study was designed to investigate the effect of Vitamin D as an add-on therapy in patients of Type 2 DM whose glycemic status was uncontrolled with oral antidiabetic drugs.

Methods: This was a before and after, open labeled study of 12 weeks duration, conducted on 50 patients of Type 2 DM and Vitamin D deficiency. These patients were given 60,000 IU of Vitamin D3 orally/week for 12 weeks in addition to oral antidiabetic drugs. Effect of Vitamin D was observed on HbAIC, fasting blood glucose (FBG), 25(OH)D and calcium levels.

Results: At the end of 12 weeks, a highly significant reduction (p<0.001) was seen in FBG levels and HbAIC decreased significantly (p<0.05). Highly significant (p<0.001) increase was observed in 25(OH)D levels and calcium levels increased significantly (p<0.05). No untoward side effect was observed in any of the patients.

Conclusion: It establishes that Vitamin D therapy improves glycemic status thereby, delays the progression and consequently the complications of Type 2 DM. Therefore, supplementation of Vitamin D is a promising and safe adjuvant therapy in Vitamin D deficient Type 2 DM patients.

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