A study on anti-tubercular drug-induced adverse reactions in South Indian district tuberculosis center


  • Devesh Kumar Joshi Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Punjab, India
  • R. Yogananda Department of Pharmacy Practice, S J M College of Pharmacy, Chitradurga, Karnataka, India
  • Anand B. Geni Department of Pharmacy Practice, S J M College of Pharmacy, Chitradurga, Karnataka, India
  • Sreeharsha . TB and Chest Physician District Revised National Tuberculosis Control Programme Centre, Chitradurga, Karnataka, India




Tuberculosis, Directly observed treatment short course, Adverse drug reaction, Adverse drug event, Revised National Tuberculosis Control Programme


Background: An adverse drug reaction (ADR) is any response to a drug which is noxious and unintended occurs at doses normally used in man for prophylaxis, diagnosis or therapy of disease or the modification of physiological function, anti-tubercular drugs can cause ADR and involving almost all systems in the body including the gastrointestinal (GI) tract, liver, skin, nervous system, and eyes.

Methods: A prospective observational study was conducted on tuberculosis (TB) patient. The suspected drug identified for ADRs and the type, nature, severity of reaction were recorded. A total of 239 patients were enrolled in the study. The patient was monitored the suspected ADRs were recorded and assessed for causality and severity.

Results: Out of 239 patients, 60 (25.11%) developed one and more than one ADR. A maximum number of tubercular patients were in age group of 21-40 years (44.4%). The majority of patients were males (69%). Incidence of ADRs based on affected organ was GI system disorders (30.33%), skin and appendages disorders (23.62%), central and peripheral nervous system disorders (15.28%), musculo-skeletal system disorders and liver and biliary disorder (9.72% each), hearing disorder (5.55%), and visual disorder accounts of (2.78%).

Conclusion: TB still becomes worldwide health problem not only on developing country but also in the developed country even the number of TB patients most large in

the developing country. The importance of developing strategies to ameliorate ADRs both to improve the quality of patient care and to control TB safely.


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How to Cite

Joshi, D. K., Yogananda, R., Geni, A. B., & ., S. (2017). A study on anti-tubercular drug-induced adverse reactions in South Indian district tuberculosis center. International Journal of Basic & Clinical Pharmacology, 4(6), 1267–1270. https://doi.org/10.18203/2319-2003.ijbcp20151370



Original Research Articles