DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20151364

Toxicological studies of Anchomanes difformis Blume (Araceae) using rats and mice

Oghale Ovuakporie-Uvo, MacDonald Idu, Gerald O. Eze, Raymond I. Ozolua

Abstract


Background: The toxicity; biochemical, hematological and histopathological study of Anchomanes difformis aqueous extract was carried out.

Methods: Six groups; 0, 100, 1000, 5000, 7500, and 10,000 mg/kg p.o of mice consisting of four animals; two females, two male a group were used in the acute toxicology experimentation. For the sub-acute test, rats of either sex; three males and three females were shared into four groups; 0, 500, 1000, and 2500 mg/kg p.o for 21 days. Toxicity studies were done using automated techniques and prepared histology slides viewed under a light microscope.

Results: Results showed no mortality - undeterminable lethal dose, 50%. Biochemical parameters tested were within permissible limits and no pathologies in the selected organs studied.

Conclusion: It can be inferred that A. difformis aqueous extract is safe even at a dose as high as 10 g/kg body weight.


Keywords


Acute, Sub-acute, Anchomanes difformis, Rats, Mice

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