Evaluation of anticonvulsant activity of ethanolic extract of Momordica tuberosa leaves in experimental animals

Yasmeen A. Maniyar, Jayapradha Shivanand Totad


Background: The aim of the present study was to evaluate the anticonvulsant activity of ethanolic extract of Momordica tuberosa leaves (EEMTL) in a maximal electric shock induced seizure (MES) model in experimental animals.

Methods: A total of 30 albino rats of either sex weighing 150-200 g were randomly divided into five groups of six animals each. Group I received normal saline (0.5 ml), Group II received phenytoin sodium (25 mg/kg body weight) intraperitoneal, Group III, IV, V received different doses (100, 200, 400 mg/kg, respectively) of M. tuberosa leaves extract orally. Convulsions were produced in all groups by giving maximal electric shock of 150 mA for 0.2 sec after 1 hr of giving test and standard drugs. Tonic-clonic seizures were produced after giving an electric shock. Recovery time was noted. The period of tonus, clonus, and stupor were measured and compared between the control, standard and test.

Results: In MES model, EEMTLsignificantly (p<0.0001) decreased the duration of tonic-clonic seizures and recovery time.

Conclusion: M. tuberosa leaveswere shown anticonvulsant property in MES animal models.


Convulsions, Momordica tuberosa, Phenytoin sodium, Maximal electric shock, Anticonvulsant

Full Text:



World Health Organization. Epilepsy: Factsheet N 999, 2012. Available at Accessed 06 November 2014.

Kumar P, Devalarao G, Bilakanti L, Setty SR. Pharmacognostical studies on tubers of Momordica tuberosa Cogn. Cucurbitaceae. Rev Bras Farmacogn Braz J Pharmacogn. 2010;20(1):7-11.

Palanivel V, Shafi M, Senthil Kumar KL. Antidiabetic and hypolipidemic activities of Momordica tuberosa unripe fruit extract on diabetic induced rats. Int J Adv Pharm Genet Res. 2013;1(2):33-40.

Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd Edition. New Delhi, India: Periodical Expert Book Agency; 1991.

Vrushabendra Swamy BM, Jayaveera KN, Ravindra Reddy K, Bhrathi T. Anti- diarrhoeal activity of fruits extract of Momordica cymbalaria Hook. f. Int J Nutr Wellness. 2008;5:2.

Vangoori Y, Gadekal M, Deeepika Klnrr D, Ramesh P, Pratibha A. Evaluation of anticonvulsant activity of ethanolic extract of Momordica tuberosa in expt animals. Int J Pharm Pharm Sci. 2013;5(3):485-7.

Pramod K, Deval RG, Lakshmayya, Ramachandra SS. Antioxidant and hepatoprotective activity of tubers of Momordica tuberosa Cogn. against CCl4 induced liver injury in rats. Indian J Exp Biol. 2008;46(7):510-3.

Pramod K, Devala RG, Lakshmayya, Ramachandra SS. Nephroprotective and nitric oxide scavenging activity of tubers of Momordica tuberosa in rats. Avicenna J Med Biotechnol. 2011;3(2):87-93.

Daripelli SV, Vishwanath J, Vrushabendra Swamy BM, Anilkumar Reddy P. Antidepressant activity of hydroalcoholic extract of fruits of Momordica cymbalaria hook. F in animal models. J Chem Pharam Sci. 2011;4(4):158-62.

Dhasan PB, Jegadeesan M, Kavimani S. Antiulcer activity ofaqueous extract of fruits of M. Cymbalaria hook inwistar rats. Pharmacognosy Res. 2010;2(1):58-61.

Murthy SN, Snehalatha N, Anuradha N, Seetharam YN. Anticonvulsant activity of ethanolic extract of Momordica cymbalaria Fenzl. ex Naud. Focus Altern Complement Ther 2007;12:45-7.

Erturk O. Antibacterial and antifungal activity of ethanolic extract from eleven spice plants. Biol Bratisl. 2006;61(3):275 8.

Ezra Y, Muneer S, Mansoor M, Srinivas Rao D. In vitro antioxidant and hypolipidemic activity of Momordica cymbalaria Fenzl in wistar rats. J Pharm Res. 2014;3(8):172 5.

Merritt HH, Putnam TJ. A new series of anticonvulsant drugs tested by experiments on animals. Arch Neurol Psychiatry. 1938;39:1003-15.

Porter RJ, Cereghino JJ, Gladding GD, Hessie BJ, Kupferberg HJ, Scoville B, et al. Antiepileptic Drug Development Program. Cleve Clin Q. 1984;51(2):293-305.

Kohli K, Gupta M, Tejwani S. Contemporary Perspectives of Clinical Pharmacotherapeutics. 1st Edition. New Delhi: Elsevier A Division of Reed Elsevier India Private Limited; 2006: 40.