DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20151336

Assessment of Curcuma longa linn. on learning and memory in rats

K. Lohit, Naveen Anthony, Amruta A. Pandit, Jesso George, Maria Jose, Mangala Rao, Denis Xavier

Abstract


Background: There is an increase in elderly population and memory-related disorders. Curcuma longa linn. can induce cognitive improvement due to its antioxidant effects. This study evaluated the effect of chronic administration of C. longa linn. on learning and memory in rats.

Methods: Twenty four female Albino Wistar rats were randomized into control, standard, and test groups. The control group received 0.5% methyl cellulose; the standard group received piracetam and test group received C. longa orally for 24 days. Water maze and step-through passive avoidance test were used to evaluate the effect of C. longa linn. on learning and memory. Water maze training was done from day 23 to day 26. Assessment of spatial memory was done on day 27 and retention memory on day 29.

Results: The mean escape latency (EL) in control, standard, and test group was 42.48, 30.45, and 30.88 sec on day 23 which decreased to 11.08, 11.36, and 9.66 sec on day 26, respectively. The EL in all the three groups decreased from day 23 to day 26 (p<0.01). The time spent in the target quadrant was more in the test group (21.25 sec) compared to control (19.73 sec) and standard group (19.79 sec) (p=0.768). In passive avoidance test, test group showed a trend toward improvement in retention memory (p=0.293).

Conclusion: C. longa linn. may be useful in enhancing learning. Further dose ranging preclinical studies are required to evaluate the efficacy of curcumin on memory.


Keywords


Curcuma longa, Spatial memory, Step-through passive avoidance, Water maze

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References


Parle M, Singh N, Vasudevan M. Regular rehearsal helps in consolidation of long term memory. J Sports Sci Med. 2006;5(1):80-8.

Izquierdo I, Medina JH, Vianna MR, Izquierdo LA, Barros DM. Separate mechanisms for short- and long-term memory. Behav Brain Res. 1999;103(1):1-11.

Qiu C, Kivipelto M, von Strauss E. Epidemiology of Alzheimer’s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci. 2009;11(2):111-28.

Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, et al. Global prevalence of dementia: a Delphi consensus study. Lancet. 2005;366(9503):2112-7.

Riordan KC, Hoffman Snyder CR, Wellik KE, Caselli RJ, Wingerchuk DM, Demaerschalk BM. Effectiveness of adding memantine to an Alzheimer dementia treatment regimen which already includes stable donepezil therapy: a critically appraised topic. Neurologist. 2011;17(2):121-3.

Qaseem A, Snow V, Cross JT Jr, Forciea MA, Hopkins R Jr, Shekelle P, et al. Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med. 2008;148(5):370-8.

Howes MJ, Houghton PJ. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol Biochem Behav. 2003;75(3):513-27.

Ringman JM, Frautschy SA, Cole GM, Masterman DL, Cummings JL. A potential role of the curry spice curcumin in Alzheimer’s disease. Curr Alzheimer Res. 2005;2(2):131-6.

Lantz RC, Chen GJ, Solyom AM, Jolad SD, Timmermann BN. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine. 2005;12(6-7):445-52.

Winblad B. Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev. 2005;11(2):169-82.

He Z, Liao Y, Zheng M, Zeng FD, Guo LJ. Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Cell Mol Neurobiol. 2008;28(4):613-27.

Singh N, Parle M. Sildenafil improves acquisition and retention of memory in mice. Indian J Physiol Pharmacol. 2003;47(3):318-24.

Pan R, Qiu S, Lu DX, Dong J. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin Med J (Engl). 2008;121(9):832-9.

Pyrzanowska J, Piechal A, Blecharz-Klin K, Lehner M, Skórzewska A, Turzynska D, et al. The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharmacol Biochem Behav. 2010;95(3):351-8.