Evaluation of anti-psychotic effect of nimodipine using methylphenidate as a model to induce psychosis in albino mice


  • Hemant Tanwani Department of Pharmacology, M.G.M. Medical College, Indore, MP, India
  • Sheetal P. Pandey Madhya Pradesh Medical Science University, Jabalpur, MP, India
  • Shubham Atal Department of Pharmacology, M.G.M. Medical College, Indore, MP, India
  • Prem Nyati Department of Pharmacology Index Medical College and Research Center, Indore, Jabalpur, MP, India




Nimodipine, Methylphenidate, Psychosis, Haloperidol, Stereotypy, Catalepsy


Background: Schizophrenia is a functional psychotic disorder currently treated by typical and atypical antipsychotic drugs. A large group of patients remain resistant to therapy. Nimodipine has been found effective for treating resistant bipolar mood disorder which is linked genetically with schizophrenia and has a high overlap of neurotransmitters in the etiopathology. Previous studies to evaluate nimodipine’s antipsychotic activity have shown inconsistent results. Methylphenidate, a CNS stimulant like amphetamine, has been shown to induce stereotypy in animals and can be proposed as an alternative model for psychosis.

Methods: Methylphenidate 5 mg/kg was given intraperitoneally to induce psychosis in swiss albino mice (n=6). Nimodipine was given alone in doses of 2.5 and 5 mg/kg by i.p route and in combination with haloperidol 0.1 mg/kg and effects were compared with haloperidol 0.2mg/kg. Activity of nimodipine was also assessed on the haloperidol induced catalepsy test. Statistical analysis was done with ANOVA followed by Bonferroni’s test using SPSS v. 20.0.

Results: Methylphenidate successfully induced characteristic stereotypy behaviour in mice similar to amphetamine. Both nimodipine 5 mg/kg and haloperidol 0.2 mg/kg showed significant reduction in stereotypy behaviour with no statistical difference between the two; result with nimodipine were only slightly inferior to haloperidol. Nimodipine 5 mg/kg with haloperidol 0.1 mg/kg showed significantly better activity than haloperidol in standard dose of 0.2 mg/kg. Nimodipine did not show significant activity on the haloperidol induced catalepsy test.

Conclusions: Methylphenidate has potential to be used as an alternative model for inducing psychosis in animals and nimodipine shows promising results for use as adjuvant antipsychotic drug.


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How to Cite

Tanwani, H., Pandey, S. P., Atal, S., & Nyati, P. (2017). Evaluation of anti-psychotic effect of nimodipine using methylphenidate as a model to induce psychosis in albino mice. International Journal of Basic & Clinical Pharmacology, 4(6), 1047–1053. https://doi.org/10.18203/2319-2003.ijbcp20151210



Original Research Articles