Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation


  • Ramesh Rooprai Rai Specialty Care Centre, Shyam Nagar, Jaipur, Rajasthan 302019, India
  • Naresh Bhat Columbia Asia Hospital, Kirloskar Business Park, Vinayakanagar, Bengaluru, Karnataka 560024, India
  • Rajesh Sainani Sainani Medicare Clinic, 401, Doctor House, Haji Ali, Mumbai 400034, India
  • Mayur M. Mayabhate Abbott India Limited, 271, Business Park, 7th floor, Model Industrial Colony, Off Aarey Road, Goregoan (E), Mumbai, Maharashtra 400063, India



Constipation scoring system, Co-morbid conditions, Laxatives, PAC-SYM, PAC-QoL


Background: Evaluate prevalence of functional constipation (FC) and irritable bowel syndrome-constipation (IBS-C) in Indian constipated patients and assess their demographic/socio-economic/clinical characteristics.

Methods: Patients (≥18 years) who visited their general physician with symptoms of constipation (Rome III criteria for FC or IBS-C as per physician assessment) and willing to participate were enrolled in this prospective, clinical-epidemiological study. Demographic, socioeconomic status, lifestyle and dietary habits, comorbid conditions, treatment history, concomitant medications, stool form (Bristol stool form scale), severity of constipation (constipation scoring system [CSS]), constipation-related symptoms (patient assessment of constipation symptoms [PAC-SYM]) and quality of life (patient assessment of constipation-quality of life questionnaire [PAC-QoL]) were recorded.

Results: Out of 925 constipated patients, 75.6% were diagnosed with FC against 24.4% with IBS-C (P < 0.0001). Patients of both subtypes had high average scores of PAC-SYM (FC: 27.1 ± 6; IBS-C: 30.1 ± 4.9) and CSS (FC: 8.4 ± 3.1; IBS-C: 11.2 ± 3), leading to high PAC-QoL score (FC: 38.1 ± 16.8; IBS-C: 42.2 ± 13.6). Hypertension (16%) and diabetes (10%) in patients with FC while acid peptic disorders (21.7%) amongst IBS-C patients were the most common comorbid conditions observed. Laxatives were the most common medication used; osmotic (32.6% versus 40.7%) and bulk laxatives (22.8% versus 37.4%) were the commonest laxatives. However, about 1/5th patients of FC were using home remedies.

Conclusions: There was a higher prevalence of FC over IBS-C in Indian constipated patients; both subtypes had high frequency and severity of constipation-related symptoms and poor QoL.


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How to Cite

Rooprai, R., Bhat, N., Sainani, R., & Mayabhate, M. M. (2017). Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation. International Journal of Basic & Clinical Pharmacology, 6(2), 275–285.



Original Research Articles