DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20163250

Drug utilization pattern of fixed drug combination of antipyretic and analgesic in paediatrics department of Gauhati medical college and hospital, Guwahati, Assam, India

Binita Singha, Syed Adam Mousum, Mangala Lahkar, Ajoy Borah

Abstract


Background: Fever and pain are the most common symptoms prompting patients to seek medical attention. This study was planned to study the drug utilization pattern of fixed drug combination of antipyretic and analgesic compared to paracetamol in paediatrics department of Gauhati Medical College and Hospital.

Methods: It was a prescription based cross-sectional study where Prescriptions with fixed dose combination of antipyretic and analgesic and prescriptions with paracetamol were observed. Demographic characteristics such as age, sex and indications were also recorded. The data were analysed for the utilization pattern of antipyretic and analgesic combination and compared with prescriptions with paracetamol alone without any other analgesic combination.

Results: Out of 266 prescriptions screened 110 were prescribed with fixed dose antipyretic- analgesic combination while 156 were prescribed with paracetamol alone. The antipyretic - analgesic combination was composed of paracetamol and ibuprofen. This combination was prescribed in most of the post-operative cases and in cases with pain for various causes. Fever was the most common condition where only paracetamol and no other analgesic were prescribed. Percentage of combination prescribed was highest in children between 10 - 14 years of age and least in infants.

Conclusions: This study shows the increase utilization of antipyretic-analgesic combinations in various conditions and the preference of fixed dose combination over paracetamol increases with increase in age of the paediatric patients.


Keywords


Ibuprofen, Paracetamol, Prescription study, Children

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References


Tripathi KD. Essentials of medical pharmacology. 7th edition, Jaypee Brothers Medical Publishers (P) Ltd; 2013:193.

Knoebel EE, Narang AS, Ey IL. Fever: to treat or not to treat. Clin Pediatr (Phila). 2002;41:9-16.

Ghai OP, Paul VK, Bagga A. Ghai essential pediatrics. 7th edition, CBS Publishers and Distributers Pvt Ltd.; 2009:181-182.

Litalian C, Jackz-Aigrain E. Risks and benefits of non-steroidal anti-inflammatory drugs in children: a comparison with paracetamol. Pediatr Drugs. 2001;3:817-18.

Sullivan JE, Farrar HC. Fever and antipyretic use in children. Pediatrics. 2011;127(3):580-7.

Brunton LL, Chabner BA, Knollman BC. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 12th edition, McGraw-Hill; 2011:428-469.

Pincus T, Swearingen C, Cummine P, Callahaw LP. Preference for non-steroidal anti-inflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. J Rheumatol. 2000;27:1020-7.

American academy of pediatrics, committee on drugs, acetaminophen toxicity in children. Paediatrics. 2001;108:1020-4.

Carson SM. Alternating acetaminophen and Ibuprofen in the febrile child: examination of the evidence regarding efficacy and safety. Pediatr Nurs. 2003;29:379-82.

Tripathi KD. Essentials of Medical Pharmacology. 7th edition, Jaypee Brothers Medical Publishers (P) Ltd; 2013:209.

Smith C, Goldman R. Alternating acetaminophen and ibuprofen for pain in children. Can Fam Physician. 2012;58:645-7.

Sullivan JE, Farrar HC. Fever and antipyretic use in children. Pediatrics. 2011;127:580-7.

Ong C, Seymour R, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with non-steroidal anti-inflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110:1170-9.

Prymula R, Siegrist C, Chibek R, Zemlickova H, Vackova M, Smetana J, et al. Effect on prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomized controlled trials. Lancet. 2009;374:1339-50.

Donati M, Monaco L, Melis M, Sottosanti L, Biagi C, Vaccheri A, et al. Ibuprofen-associated hypothermia in children: analysis of the Italian spontaneous reporting database. Eur J Clin Pharmacol, 2016. Available at http://www.ncbi.nlm.nih.gov/pubmed/27417946.